HTR1B - 5-hydroxytryptamine receptor 1B - human protein (Function)
 
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HTR1B »  5-hydroxytryptamine receptor 1B  (5-HT1B)
 
Protein also known as:  Serotonin 1D beta receptor (5-HT-1D-beta).
Gene name:  HTR1B
Entry whose protein(s) existence is based on evidence at protein level
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1 38 1
GENE REF ISO

Function

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Overview 
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.  
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  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.3.6  
GO molecular function 
Drug bindingdefinition[GO:0008144] silver  
  • IEAOrtholog Compara
Serotonin bindingdefinition[GO:0051378] silver  
  • IEAOrtholog Compara
Serotonin receptor activitydefinition[GO:0004993]  
1
  • IDAUniProtKB
GO biological process 
Adenylate cyclase-inhibiting serotonin receptor signaling pathwaydefinition[GO:0007198]  
1
  • IDAUniProtKB
Bone remodelingdefinition[GO:0046849] silver  
  • IEAOrtholog Compara
Cellular response to alkaloiddefinition[GO:0071312]  
1
  • IDAUniProtKB
Cellular response to drugdefinition[GO:0035690]  
1
  • IDAUniProtKB
Cellular response to temperature stimulusdefinition[GO:0071502] silver  
  • IEAOrtholog Compara
Drinking behaviordefinition[GO:0042756] silver  
  • IEAOrtholog Compara
G-protein coupled receptor internalizationdefinition[GO:0002031] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
1
  • TASPINC
Negative regulation of cAMP biosynthetic processdefinition[GO:0030818]  
1
  • IDAUniProtKB
Negative regulation of serotonin secretiondefinition[GO:0014063]  
  • ISSOrtholog Curator
Negative regulation of synaptic transmission, GABAergicdefinition[GO:0032229] silver  
  • IEAOrtholog Compara
Negative regulation of synaptic transmission, glutamatergicdefinition[GO:0051967] silver  
  • IEAOrtholog Compara
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205] silver  
  • IEAOrtholog Compara
Regulation of behaviordefinition[GO:0050795] silver  
  • IEAInterPro 2 GO
Regulation of dopamine secretiondefinition[GO:0014059] silver  
  • IEAOrtholog Compara
Response to cocainedefinition[GO:0042220] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to mineralocorticoiddefinition[GO:0051385] silver  
  • IEAOrtholog Compara
Synaptic transmissiondefinition[GO:0007268] silver  
  • IEAOrtholog Compara
Vasoconstrictiondefinition[GO:0042310] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+3351  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
Serotonin receptors  REACT_17064  
Note 
A residue in the 7th transmembrane region (Thr-355 in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Behavior  definition   [KW-0085]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: 5-HT1B_receptor
GenomeRNAi: 3351
PRO: PR:P28222
Chemistry
GuidetoPHARMACOLOGY: 2