HTR2A - 5-hydroxytryptamine receptor 2A - human protein (Function)
 
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HTR2A »  5-hydroxytryptamine receptor 2A  (5-HT-2)
 
Protein also known as:  Serotonin receptor 2A.
Gene name:  HTR2A
Entry whose protein(s) existence is based on evidence at protein level
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1 324 2
GENE REF ISO

Function

 show evidences
Overview 
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.  
7
  • UniProtKB
GO molecular function 
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingdefinition[GO:0071886]  
1
  • UniProtKB
Drug bindingdefinition[GO:0008144]  
3
  • UniProtKB
G-protein alpha-subunit bindingdefinition[GO:0001965] silver  
1
  • Ortholog Compara
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Serotonin bindingdefinition[GO:0051378]  
4
  • UniProtKB
  • MGI
Serotonin receptor activitydefinition[GO:0004993]  
2
  • UniProtKB
  • MGI
GO biological process 
Activation of phospholipase C activitydefinition[GO:0007202]  
1
  • UniProtKB
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Artery smooth muscle contractiondefinition[GO:0014824] silver  
1
  • Ortholog Compara
Behavioral response to cocainedefinition[GO:0048148] silver  
1
  • Ortholog Compara
Cell deathdefinition[GO:0008219] silver  
1
  • Ortholog Compara
Cellular calcium ion homeostasisdefinition[GO:0006874]  
2
  • UniProtKB
Detection of mechanical stimulus involved in sensory perception of paindefinition[GO:0050966] silver  
1
  • Ortholog Compara
Detection of temperature stimulus involved in sensory perception of paindefinition[GO:0050965] silver  
1
  • Ortholog Compara
Memorydefinition[GO:0007613] silver  
1
  • Ortholog Compara
Negative regulation of potassium ion transportdefinition[GO:0043267] silver  
1
  • Ortholog Compara
Negative regulation of synaptic transmission, glutamatergicdefinition[GO:0051967] silver  
1
  • Ortholog Compara
Phosphatidylinositol 3-kinase signalingdefinition[GO:0014065]  
1
  • UniProtKB
Phospholipase C-activating serotonin receptor signaling pathwaydefinition[GO:0007208] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • UniProtKB
Positive regulation of fat cell differentiationdefinition[GO:0045600] silver  
1
  • Ortholog Compara
Positive regulation of glycolytic processdefinition[GO:0045821] silver  
1
  • Ortholog Compara
Positive regulation of MAP kinase activitydefinition[GO:0043406] silver  
1
  • Ortholog Compara
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731] silver  
1
  • Ortholog Compara
Positive regulation of phosphatidylinositol biosynthetic processdefinition[GO:0010513]  
1
  • UniProtKB
Positive regulation of vasoconstrictiondefinition[GO:0045907] silver  
1
  • Ortholog Compara
Protein localization to cytoskeletondefinition[GO:0044380] silver  
1
  • Ortholog Compara
Regulation of behaviordefinition[GO:0050795] silver  
1
  • InterPro 2 GO
Regulation of dopamine secretiondefinition[GO:0014059] silver  
1
  • Ortholog Compara
Regulation of hormone secretiondefinition[GO:0046883] silver  
1
  • InterPro 2 GO
Release of sequestered calcium ion into cytosoldefinition[GO:0051209]  
2
  • UniProtKB
Response to drugdefinition[GO:0042493]  
2
  • UniProtKB
Serotonin receptor signaling pathwaydefinition[GO:0007210]  
1
  • UniProtKB
Sleepdefinition[GO:0030431] silver  
1
  • Ortholog Compara
Synaptic transmissiondefinition[GO:0007268]  
1
  • PINC
Temperature homeostasisdefinition[GO:0001659] silver  
1
  • Ortholog Compara
Urinary bladder smooth muscle contractiondefinition[GO:0014832] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+3356  
Gap junction  hsa04540+3356  
Neuroactive ligand-receptor interaction  hsa04080+3356  
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
Serotonin receptors  REACT_17064  
 

Keywords

Biological process 
Behavior  definition   [KW-0085]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: 5-HT2A_receptor
GenomeRNAi: 3356
PRO: PR:P28223
Chemistry
GuidetoPHARMACOLOGY: 6