CHAT - Choline O-acetyltransferase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CHAT »  Choline O-acetyltransferase   [ EC 2.3.1.6 ]  (ChAT)
 
Gene name:  CHAT
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 60 3
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.  
  • CuratedUniProtKB
GO molecular function 
Choline O-acetyltransferase activitydefinition[GO:0004102]  
  • IEAEC 2 GO
GO biological process 
Adult walking behaviordefinition[GO:0007628] silver  
  • IEAOrtholog Compara
Dendrite developmentdefinition[GO:0016358] silver  
  • IEAOrtholog Compara
Establishment of synaptic specificity at neuromuscular junctiondefinition[GO:0007529] silver  
  • IEAOrtholog Compara
Muscle organ developmentdefinition[GO:0007517] silver  
  • IEAOrtholog Compara
Neuromuscular synaptic transmissiondefinition[GO:0007274] silver  
  • IEAOrtholog Compara
Neurotransmitter biosynthetic processdefinition[GO:0042136]  
  • IEAUniProtKB KW
Rhythmic behaviordefinition[GO:0007622] silver  
  • IEAOrtholog Compara
Rhythmic excitationdefinition[GO:0043179] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.6: Acetyl-CoA + choline CoA + O-acetylcholine.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+1103  
Glycerophospholipid metabolism  hsa00564+1103  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Neurotransmitter biosynthesis  definition   [KW-0530]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P28329
Other
GeneWiki: Choline_acetyltransferase
GenomeRNAi: 1103
PRO: PR:P28329