ACADL - Long-chain specific acyl-CoA dehydrogenase, mitochondrial - human protein (Function)
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ACADL »  Long-chain specific acyl-CoA dehydrogenase, mitochondrial   [ EC ]  (LCAD)
Gene name:  ACADL
Family name: Acyl-CoA dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
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GO molecular function 
Fatty-acyl-CoA bindingdefinition[GO:0000062] silver  
  • IEAOrtholog Compara
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAOrtholog Compara
Long-chain-acyl-CoA dehydrogenase activitydefinition[GO:0004466]  
  • ISSOrtholog Curator
Palmitoyl-CoA oxidase activitydefinition[GO:0016401]  
  • ISSOrtholog Curator
GO biological process 
Carnitine catabolic processdefinition[GO:0042413]  
  • ISSOrtholog Curator
Carnitine metabolic process, CoA-linkeddefinition[GO:0019254]  
  • ISSOrtholog Curator
Cellular lipid catabolic processdefinition[GO:0044242]  
  • ISSOrtholog Curator
Fatty acid beta-oxidation using acyl-CoA dehydrogenasedefinition[GO:0033539]  
  • ISSOrtholog Curator
Long-chain fatty acid catabolic processdefinition[GO:0042758] silver  
  • IEAOrtholog Compara
Negative regulation of fatty acid biosynthetic processdefinition[GO:0045717]  
  • ISSOrtholog Curator
Negative regulation of fatty acid oxidationdefinition[GO:0046322]  
  • ISSOrtholog Curator
Oxidation-reduction processdefinition[GO:0055114]  
  • ISSOrtholog Curator
Protein homotetramerizationdefinition[GO:0051289] silver  
  • IEAOrtholog Compara
Regulation of cholesterol metabolic processdefinition[GO:0090181]  
  • ISSOrtholog Curator
Temperature homeostasisdefinition[GO:0001659]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC Long-chain-acyl-CoA + electron-transfer flavoprotein long-chain-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
  • CuratedUniProtKB
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Fatty acid metabolism  hsa00071+33  
Metabolic pathways  hsa01100+33  
PPAR signaling pathway  hsa03320+33  
According to Reactome, this protein belongs to the following pathways:
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA  REACT_735  
Beta oxidation of myristoyl-CoA to lauroyl-CoA  REACT_2108  
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids  REACT_160  
More information is available from:
A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.  
  • CuratedUniProtKB


Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

Enzyme and pathway databases
SABIO-RK: P28330
GenomeRNAi: 33
PRO: PR:P28330