HTR2C - 5-hydroxytryptamine receptor 2C - human protein (Function)
 
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HTR2C »  5-hydroxytryptamine receptor 2C  (5-HT2C)
 
Protein also known as:  5-hydroxytryptamine receptor 1C (5-HT1C).
Gene name:  HTR2C
Entry whose protein(s) existence is based on evidence at protein level
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1 120 2
GENE REF ISO

Function

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Overview 
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.  
4
  • CuratedUniProtKB
GO molecular function 
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingdefinition[GO:0071886]  
1
  • IDAUniProtKB
Drug bindingdefinition[GO:0008144]  
3
  • IDAUniProtKB
Gq/11-coupled serotonin receptor activitydefinition[GO:0001587]  
1
  • IDAUniProtKB
Serotonin bindingdefinition[GO:0051378]  
3
  • IDAUniProtKB
  • IDAMGI
Serotonin receptor activitydefinition[GO:0004993]  
1
  • IDAMGI
GO biological process 
Behavioral fear responsedefinition[GO:0001662]  
  • ISSOrtholog Curator
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • IDAUniProtKB
cGMP biosynthetic processdefinition[GO:0006182]  
1
  • IDAUniProtKB
Feeding behaviordefinition[GO:0007631]  
  • ISSOrtholog Curator
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAInterPro 2 GO
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
1
  • IDAUniProtKB
Phospholipase C-activating serotonin receptor signaling pathwaydefinition[GO:0007208]  
  • ISSOrtholog Curator
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwaydefinition[GO:0051482]  
  • ISSOrtholog Curator
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IDAUniProtKB
Positive regulation of phosphatidylinositol biosynthetic processdefinition[GO:0010513]  
1
  • IDAUniProtKB
Regulation of appetitedefinition[GO:0032098]  
  • ISSOrtholog Curator
Regulation of corticotropin-releasing hormone secretiondefinition[GO:0043397]  
  • ISSOrtholog Curator
Regulation of neurological system processdefinition[GO:0031644]  
  • ISSOrtholog Curator
Release of sequestered calcium ion into cytosoldefinition[GO:0051209]  
1
  • IMPUniProtKB
Response to drugdefinition[GO:0042493]  
1
  • IDAUniProtKB
Serotonin receptor signaling pathwaydefinition[GO:0007210]  
1
  • IMPUniProtKB
Synaptic transmissiondefinition[GO:0007268]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+3358  
Gap junction  hsa04540+3358  
Neuroactive ligand-receptor interaction  hsa04080+3358  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Behavior  definition   [KW-0085]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: 5-HT2C_receptor
GenomeRNAi: 3358
PRO: PR:P28335
Chemistry
GuidetoPHARMACOLOGY: 8