HTR1E - 5-hydroxytryptamine receptor 1E - human protein (Function)
 
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HTR1E »  5-hydroxytryptamine receptor 1E  (5-HT1E)
 
Protein also known as:  Serotonin receptor 1E.
Gene name:  HTR1E
Entry whose protein(s) existence is based on evidence at transcript level
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1 30 1
GENE REF ISO

Function

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Overview 
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.  
5
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASPINC
Serotonin bindingdefinition[GO:0051378]  
1
  • IDAMGI
Serotonin receptor activitydefinition[GO:0004993]  
2
  • IMPUniProtKB
  • IDAMGI
GO biological process 
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193]  
1
  • IMPUniProtKB
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
1
  • TASPINC
Negative regulation of cAMP metabolic processdefinition[GO:0030815] silver  
  • IEAInterPro 2 GO
Serotonin receptor signaling pathwaydefinition[GO:0007210]  
2
  • IMPGOC
Synaptic transmissiondefinition[GO:0007268] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+3354  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: 5-HT1E_receptor
GenomeRNAi: 3354
PRO: PR:P28566
Chemistry
GuidetoPHARMACOLOGY: 4