ERCC5 - DNA repair protein complementing XP-G cells - human protein (Function)
 
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ERCC5 »  DNA repair protein complementing XP-G cells
 
Gene name:  ERCC5
Family name: XPG/RAD2 endonuclease » XPG
Entry whose protein(s) existence is based on evidence at protein level
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1 114 3
GENE REF ISO

Function

 show evidences
Overview 
Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.  
  • CuratedUniProtKB
GO molecular function 
Bubble DNA bindingdefinition[GO:0000405]  
1
  • IDAUniProtKB
Double-stranded DNA bindingdefinition[GO:0003690]  
2
  • IDAUniProtKB
Endodeoxyribonuclease activitydefinition[GO:0004520]  
2
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Protein N-terminus bindingdefinition[GO:0047485]  
1
  • IPIUniProtKB
Single-stranded DNA bindingdefinition[GO:0003697]  
1
  • IDAUniProtKB
GO biological process 
DNA catabolic process, endonucleolyticdefinition[GO:0000737]  
2
  • IDAGOC
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
Nucleotide-excision repair, DNA incision, 3'-to lesiondefinition[GO:0006295]  
2
  • IMPUniProtKB
Response to UVdefinition[GO:0009411]  
2
  • IMPUniProtKB
Response to UV-Cdefinition[GO:0010225]  
1
  • IMPUniProtKB
Transcription-coupled nucleotide-excision repairdefinition[GO:0006283]  
1
  • IMPUniProtKB
UV protectiondefinition[GO:0009650]  
1
  • IGIMGI
Enzymatic activity 
It requires the following cofactor
Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding (By similarity).  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Dual incision reaction in GG-NER  REACT_311  
Dual incision reaction in TC-NER  REACT_2222  
Formation of incision complex in GG-NER  REACT_257  
Formation of transcription-coupled NER (TC-NER) repair complex  REACT_1941  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Molecular function 
Endonuclease  definition   [KW-0255]
Hydrolase  definition   [KW-0378]
Nuclease  definition   [KW-0540]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ERCC5
GenomeRNAi: 2073
PRO: PR:P28715