CD34 - Hematopoietic progenitor cell antigen CD34 - human protein (Function)
 
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Protein
Gene
References

 
CD34 »  Hematopoietic progenitor cell antigen CD34
 
Protein also known as:  CD antigen CD34.
Gene name:  CD34
Family name: CD34
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.  
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  • UniProtKB
GO molecular function 
Carbohydrate bindingdefinition[GO:0030246]  
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  • HGNC
Sulfate bindingdefinition[GO:0043199] silver  
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  • Ortholog Compara
Transcription factor bindingdefinition[GO:0008134]  
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  • UniProtKB
GO biological process 
Cell motilitydefinition[GO:0048870]  
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  • UniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • Ortholog Curator
Endothelial cell proliferationdefinition[GO:0001935]  
1
  • UniProtKB
Endothelium developmentdefinition[GO:0003158]  
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  • UniProtKB
Extracellular exosome assemblydefinition[GO:0071971]  
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  • UniProtKB
Glomerular endothelium developmentdefinition[GO:0072011]  
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  • UniProtKB
Glomerular filtrationdefinition[GO:0003094]  
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  • UniProtKB
Hematopoietic stem cell proliferationdefinition[GO:0071425]  
1
  • UniProtKB
Hemopoiesisdefinition[GO:0030097]  
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  • UniProtKB
Leukocyte migrationdefinition[GO:0050900]  
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  • Ortholog Curator
Mesangial cell-matrix adhesiondefinition[GO:0035759]  
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  • Ortholog Curator
Metanephric glomerular mesangial cell differentiationdefinition[GO:0072254]  
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  • UniProtKB
Negative regulation of blood coagulationdefinition[GO:0030195]  
1
  • UniProtKB
Negative regulation of cellular response to heatdefinition[GO:1900035]  
1
  • UniProtKB
Negative regulation of cellular response to hypoxiadefinition[GO:1900038]  
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  • UniProtKB
Negative regulation of gene expressiondefinition[GO:0010629]  
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  • UniProtKB
Negative regulation of interleukin-2 secretiondefinition[GO:1900041]  
1
  • UniProtKB
Negative regulation of neuron deathdefinition[GO:1901215]  
1
  • UniProtKB
Negative regulation of nitric oxide biosynthetic processdefinition[GO:0045019]  
1
  • UniProtKB
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720]  
1
  • UniProtKB
Paracrine signalingdefinition[GO:0038001]  
1
  • UniProtKB
Positive regulation of angiogenesisdefinition[GO:0045766]  
2
  • UniProtKB
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • UniProtKB
Positive regulation of glial cell line-derived neurotrophic factor secretiondefinition[GO:1900168]  
1
  • UniProtKB
Positive regulation of granulocyte colony-stimulating factor productiondefinition[GO:0071657]  
2
  • UniProtKB
Positive regulation of interleukin-10 productiondefinition[GO:0032733]  
1
  • UniProtKB
Positive regulation of odontogenesisdefinition[GO:0042482]  
1
  • UniProtKB
Positive regulation of transforming growth factor beta productiondefinition[GO:0071636]  
1
  • UniProtKB
Positive regulation of vasculogenesisdefinition[GO:2001214]  
1
  • UniProtKB
Regulation of blood pressuredefinition[GO:0008217]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
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  • UniProtKB
Single organismal cell-cell adhesiondefinition[GO:0016337]  
1
  • HGNC
Stem cell proliferationdefinition[GO:0072089]  
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  • UniProtKB
Tissue homeostasisdefinition[GO:0001894]  
1
  • UniProtKB
Transdifferentiationdefinition[GO:0060290]  
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  • UniProtKB
Vascular wound healingdefinition[GO:0061042]  
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  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell adhesion molecules (CAMs)  hsa04514+947  
Hematopoietic cell lineage  hsa04640+947  
According to Reactome, this protein belongs to the following pathway:
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell  REACT_11152  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD34
GenomeRNAi: 947
PRO: PR:P28906