TNFRSF8 - Tumor necrosis factor receptor superfamily member 8 - human protein (Function)
 
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Protein
Gene
References

 
TNFRSF8 »  Tumor necrosis factor receptor superfamily member 8
 
Protein also known as:  Lymphocyte activation antigen CD30; CD antigen CD30.
Gene name:  TNFRSF8
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.  
  • CuratedUniProtKB
GO molecular function 
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • TASPINC
Tumor necrosis factor-activated receptor activitydefinition[GO:0005031]  
1
  • RCAUniProtKB
GO biological process 
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • IEPUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IDAUniProtKB
Positive regulation of TRAIL biosynthetic processdefinition[GO:0045556]  
1
  • IDAUniProtKB
Positive regulation of tumor necrosis factor biosynthetic processdefinition[GO:0042535]  
1
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Tumor necrosis factor-mediated signaling pathwaydefinition[GO:0033209]  
1
  • RCAGOC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cytokine-cytokine receptor interaction  hsa04060+943  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CD30
GenomeRNAi: 943
PRO: PR:P28908
Chemistry
GuidetoPHARMACOLOGY: 1877