PCSK1 - Neuroendocrine convertase 1 - human protein (Function)
 
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PCSK1 »  Neuroendocrine convertase 1   [ EC 3.4.21.93 ]  (NEC 1)
 
Protein also known as:  Proprotein convertase 1 (PC1).
Gene name:  PCSK1
Family name: Peptidase S8 » Furin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 28 2
GENE REF ISO

Function

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Overview 
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.  
  • CuratedUniProtKB
GO molecular function 
Serine-type endopeptidase activitydefinition[GO:0004252]  
  • IBARefGenome
  • ISSOrtholog Curator
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Metabolic processdefinition[GO:0008152]  
1
  • TASPINC
Peptide biosynthetic processdefinition[GO:0043043]  
  • ISSOrtholog Curator
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.93: Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.  
  • CuratedUniProtKB
It requires the following cofactor
Calcium.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Insulin processing  REACT_15550  
Peptide hormone biosynthesis  REACT_15452  
Synthesis, secretion, and deacylation of Ghrelin  REACT_19189  
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)  REACT_24019  
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)  REACT_23824  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Proprotein_convertase_1
GenomeRNAi: 5122
PRO: PR:P29120