ADORA2A - Adenosine receptor A2a - human protein (Function)
 
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ADORA2A »  Adenosine receptor A2a
 
Gene name:  ADORA2A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.  
1
  • UniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
G-protein coupled adenosine receptor activitydefinition[GO:0001609]  
2
  • UniProtKB
Identical protein bindingdefinition[GO:0042802]  
2
  • IntAct
Protein bindingdefinition[GO:0005515]  
7
  • IntAct
  • UniProtKB
GO biological process 
Adenosine receptor signaling pathwaydefinition[GO:0001973] silver  
1
  • InterPro 2 GO
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • PINC
Apoptotic processdefinition[GO:0006915]  
1
  • PINC
Blood circulationdefinition[GO:0008015]  
1
  • PINC
Blood coagulationdefinition[GO:0007596]  
1
  • PINC
cAMP biosynthetic processdefinition[GO:0006171]  
1
  • PINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Cellular defense responsedefinition[GO:0006968]  
1
  • PINC
Central nervous system developmentdefinition[GO:0007417]  
1
  • PINC
Inflammatory responsedefinition[GO:0006954]  
1
  • PINC
Phagocytosisdefinition[GO:0006909]  
1
  • PINC
Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwaydefinition[GO:0010579]  
1
  • UniProtKB
Sensory perceptiondefinition[GO:0007600]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+135  
Neuroactive ligand-receptor interaction  hsa04080+135  
Vascular smooth muscle contraction  hsa04270+135  
According to Reactome, this protein belongs to the following pathways:
Adenosine P1 receptors  REACT_18288  
G alpha (s) signalling events  REACT_19327  
NGF-independant TRKA activation  REACT_11046  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Adenosine_A2A_receptor
GenomeRNAi: 135
PRO: PR:P29274
Chemistry
GuidetoPHARMACOLOGY: 19