ADORA2A - Adenosine receptor A2a - human protein (Function)
 
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ADORA2A »  Adenosine receptor A2a
 
Gene name:  ADORA2A
Entry whose protein(s) existence is based on evidence at protein level
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1 191 1
GENE REF ISO

Function

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Overview 
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.  
  • CuratedUniProtKB
GO molecular function 
Alpha-actinin bindingdefinition[GO:0051393] silver  
  • IEAOrtholog Compara
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
G-protein coupled adenosine receptor activitydefinition[GO:0001609]  
2
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Type 5 metabotropic glutamate receptor bindingdefinition[GO:0031802] silver  
  • IEAOrtholog Compara
GO biological process 
Adenosine receptor signaling pathwaydefinition[GO:0001973] silver  
  • IEAOrtholog Compara
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • TASPINC
Apoptotic processdefinition[GO:0006915]  
1
  • TASPINC
Astrocyte activationdefinition[GO:0048143] silver  
  • IEAOrtholog Compara
Blood circulationdefinition[GO:0008015]  
1
  • TASPINC
Blood coagulationdefinition[GO:0007596]  
1
  • TASPINC
cAMP biosynthetic processdefinition[GO:0006171]  
1
  • TASPINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Cellular defense responsedefinition[GO:0006968]  
1
  • TASPINC
Central nervous system developmentdefinition[GO:0007417]  
1
  • TASPINC
Eating behaviordefinition[GO:0042755] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Negative regulation of alpha-beta T cell activationdefinition[GO:0046636] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154] silver  
  • IEAOrtholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
  • IEAOrtholog Compara
Negative regulation of locomotiondefinition[GO:0040013] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of protein kinase activitydefinition[GO:0006469] silver  
  • IEAOrtholog Compara
Negative regulation of vascular permeabilitydefinition[GO:0043116] silver  
  • IEAOrtholog Compara
Neuron projection morphogenesisdefinition[GO:0048812] silver  
  • IEAOrtholog Compara
Phagocytosisdefinition[GO:0006909]  
1
  • TASPINC
Positive regulation of acetylcholine secretion, neurotransmissiondefinition[GO:0014057] silver  
  • IEAOrtholog Compara
Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwaydefinition[GO:0010579]  
1
  • IDAUniProtKB
Positive regulation of apoptotic signaling pathwaydefinition[GO:2001235] silver  
  • IEAOrtholog Compara
Positive regulation of circadian sleep/wake cycle, sleepdefinition[GO:0045938] silver  
  • IEAOrtholog Compara
Positive regulation of glutamate secretiondefinition[GO:0014049] silver  
  • IEAOrtholog Compara
Positive regulation of protein secretiondefinition[GO:0050714] silver  
  • IEAOrtholog Compara
Positive regulation of renal sodium excretiondefinition[GO:0035815] silver  
  • IEAOrtholog Compara
Positive regulation of synaptic transmission, GABAergicdefinition[GO:0032230] silver  
  • IEAOrtholog Compara
Positive regulation of synaptic transmission, glutamatergicdefinition[GO:0051968] silver  
  • IEAOrtholog Compara
Positive regulation of urine volumedefinition[GO:0035810] silver  
  • IEAOrtholog Compara
Prepulse inhibitiondefinition[GO:0060134] silver  
  • IEAOrtholog Compara
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205] silver  
  • IEAOrtholog Compara
Regulation of calcium ion transportdefinition[GO:0051924] silver  
  • IEAOrtholog Compara
Regulation of excitatory postsynaptic membrane potentialdefinition[GO:0060079] silver  
  • IEAOrtholog Compara
Regulation of inhibitory postsynaptic membrane potentialdefinition[GO:0060080] silver  
  • IEAOrtholog Compara
Regulation of mitochondrial membrane potentialdefinition[GO:0051881] silver  
  • IEAOrtholog Compara
Regulation of norepinephrine secretiondefinition[GO:0014061] silver  
  • IEAOrtholog Compara
Regulation of synaptic plasticitydefinition[GO:0048167] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355] silver  
  • IEAOrtholog Compara
Response to amphetaminedefinition[GO:0001975] silver  
  • IEAOrtholog Compara
Response to caffeinedefinition[GO:0031000] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Sensory perceptiondefinition[GO:0007600]  
1
  • TASPINC
Synaptic transmission, cholinergicdefinition[GO:0007271] silver  
  • IEAOrtholog Compara
Synaptic transmission, dopaminergicdefinition[GO:0001963] silver  
  • IEAOrtholog Compara
Synaptic transmission, glutamatergicdefinition[GO:0035249] silver  
  • IEAOrtholog Compara
Vasodilationdefinition[GO:0042311] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+135  
Neuroactive ligand-receptor interaction  hsa04080+135  
Vascular smooth muscle contraction  hsa04270+135  
According to Reactome, this protein belongs to the following pathways:
Adenosine P1 receptors  REACT_18288  
G alpha (s) signalling events  REACT_19327  
NGF-independant TRKA activation  REACT_11046  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Adenosine_A2A_receptor
GenomeRNAi: 135
PRO: PR:P29274
Chemistry
GuidetoPHARMACOLOGY: 19