ADORA2B - Adenosine receptor A2b - human protein (Function)
 
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ADORA2B »  Adenosine receptor A2b
 
Gene name:  ADORA2B
Entry whose protein(s) existence is based on evidence at transcript level
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1 71 1
GENE REF ISO

Function

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Overview 
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.  
  • CuratedUniProtKB
GO molecular function 
G-protein coupled adenosine receptor activitydefinition[GO:0001609] silver  
  • IEAInterPro 2 GO
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • TASPINC
Activation of MAPK activitydefinition[GO:0000187]  
1
  • TASPINC
Adenosine receptor signaling pathwaydefinition[GO:0001973] silver  
  • IEAInterPro 2 GO
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189] silver  
  • IEAOrtholog Compara
Cellular defense responsedefinition[GO:0006968]  
1
  • TASPINC
Cellular response to extracellular stimulusdefinition[GO:0031668] silver  
  • IEAOrtholog Compara
Excretiondefinition[GO:0007588]  
1
  • TASPINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
JNK cascadedefinition[GO:0007254]  
1
  • TASPINC
Positive regulation of cGMP biosynthetic processdefinition[GO:0030828] silver  
  • IEAOrtholog Compara
Positive regulation of chemokine productiondefinition[GO:0032722] silver  
  • IEAOrtholog Compara
Positive regulation of chronic inflammatory response to non-antigenic stimulusdefinition[GO:0002882] silver  
  • IEAOrtholog Compara
Positive regulation of guanylate cyclase activitydefinition[GO:0031284] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-6 productiondefinition[GO:0032755] silver  
  • IEAOrtholog Compara
Positive regulation of mast cell degranulationdefinition[GO:0043306] silver  
  • IEAOrtholog Compara
Positive regulation vascular endothelial growth factor productiondefinition[GO:0010575] silver  
  • IEAOrtholog Compara
Relaxation of vascular smooth muscledefinition[GO:0060087] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+136  
Neuroactive ligand-receptor interaction  hsa04080+136  
Vascular smooth muscle contraction  hsa04270+136  
According to Reactome, this protein belongs to the following pathways:
Adenosine P1 receptors  REACT_18288  
G alpha (s) signalling events  REACT_19327  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Adenosine_A2B_receptor
GenomeRNAi: 136
PRO: PR:P29275
Chemistry
GuidetoPHARMACOLOGY: 20