EPHA2 - Ephrin type-A receptor 2 - human protein (Function)
 
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EPHA2 »  Ephrin type-A receptor 2   [ EC 2.7.10.1 ]
 
Protein also known as:  Tyrosine-protein kinase receptor ECK.
Gene name:  EPHA2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.  
6
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Ephrin receptor activitydefinition[GO:0005003] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
Transmembrane receptor protein tyrosine kinase activitydefinition[GO:0004714]  
1
  • IDAUniProtKB
GO biological process 
Activation of Rac GTPase activitydefinition[GO:0032863]  
1
  • IMPUniProtKB
Angiogenesisdefinition[GO:0001525]  
  • IEAUniProtKB KW
Axial mesoderm formationdefinition[GO:0048320] silver  
  • IEAOrtholog Compara
Bone remodelingdefinition[GO:0046849]  
  • ISSOrtholog Curator
Branching involved in mammary gland duct morphogenesisdefinition[GO:0060444]  
  • ISSOrtholog Curator
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Cell chemotaxisdefinition[GO:0060326]  
2
  • IMPUniProtKB
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
2
  • IDAUniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630]  
1
  • IDAUniProtKB
Keratinocyte differentiationdefinition[GO:0030216]  
1
  • IMPUniProtKB
Lens fiber cell morphogenesisdefinition[GO:0070309]  
  • ISSOrtholog Curator
Mammary gland epithelial cell proliferationdefinition[GO:0033598]  
  • ISSOrtholog Curator
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Negative regulation of protein kinase B signalingdefinition[GO:0051898]  
1
  • IDAUniProtKB
Neural tube developmentdefinition[GO:0021915] silver  
  • IEAOrtholog Compara
Neuron differentiationdefinition[GO:0030182] silver  
  • IEAOrtholog Compara
Notochord cell developmentdefinition[GO:0060035] silver  
  • IEAOrtholog Compara
Notochord formationdefinition[GO:0014028] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
  • ISSOrtholog Curator
Osteoclast differentiationdefinition[GO:0030316]  
  • ISSOrtholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • IDAGOC
Positive regulation of establishment of protein localization to plasma membranedefinition[GO:0090004]  
1
  • IMPUniProtKB
Post-anal tail morphogenesisdefinition[GO:0036342] silver  
  • IEAOrtholog Compara
Protein kinase B signalingdefinition[GO:0043491]  
1
  • IDAUniProtKB
Regulation of angiogenesisdefinition[GO:0045765]  
  • ISSOrtholog Curator
Regulation of blood vessel endothelial cell migrationdefinition[GO:0043535]  
  • ISSOrtholog Curator
Regulation of cell adhesion mediated by integrindefinition[GO:0033628]  
1
  • IDAUniProtKB
Regulation of ERK1 and ERK2 cascadedefinition[GO:0070372]  
1
  • IMPUniProtKB
Regulation of lamellipodium assemblydefinition[GO:0010591]  
1
  • IMPUniProtKB
Response to growth factordefinition[GO:0070848]  
1
  • IMPUniProtKB
Skeletal system developmentdefinition[GO:0001501] silver  
  • IEAOrtholog Compara
Vasculogenesisdefinition[GO:0001570] silver  
  • IEAOrtholog Compara
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+1969  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Apoptosis  definition   [KW-0053]
Cell adhesion  definition   [KW-0130]
Differentiation  definition   [KW-0221]
Host-virus interaction  definition   [KW-0945]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPH_receptor_A2
GenomeRNAi: 1969
PRO: PR:P29317
Chemistry
GuidetoPHARMACOLOGY: 1822