EPHA2 - Ephrin type-A receptor 2 - human protein (Function)
 
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Protein
Gene
References

 
EPHA2 »  Ephrin type-A receptor 2   [ EC 2.7.10.1 ]
 
Protein also known as:  Tyrosine-protein kinase receptor ECK.
Gene name:  EPHA2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 361 2
GENE REF ISO

Function

 show evidences
Overview 
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.  
8
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Ephrin receptor activitydefinition[GO:0005003] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
8
  • UniProtKB
  • IntAct
Transmembrane receptor protein tyrosine kinase activitydefinition[GO:0004714]  
1
  • UniProtKB
GO biological process 
Activation of GTPase activitydefinition[GO:0090630]  
1
  • UniProtKB
Angiogenesisdefinition[GO:0001525]  
1
  • UniProtKB KW
Axial mesoderm formationdefinition[GO:0048320] silver  
1
  • Ortholog Compara
Bone remodelingdefinition[GO:0046849]  
1
  • Ortholog Curator
Branching involved in mammary gland duct morphogenesisdefinition[GO:0060444]  
1
  • Ortholog Curator
Cell adhesiondefinition[GO:0007155]  
1
  • UniProtKB KW
Cell chemotaxisdefinition[GO:0060326]  
2
  • UniProtKB
Cell migrationdefinition[GO:0016477]  
1
  • UniProtKB
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
2
  • UniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630]  
1
  • UniProtKB
Keratinocyte differentiationdefinition[GO:0030216]  
1
  • UniProtKB
Lens fiber cell morphogenesisdefinition[GO:0070309]  
1
  • Ortholog Curator
Mammary gland epithelial cell proliferationdefinition[GO:0033598]  
1
  • Ortholog Curator
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • PINC
Negative regulation of protein kinase B signalingdefinition[GO:0051898]  
1
  • UniProtKB
Neural tube developmentdefinition[GO:0021915] silver  
1
  • Ortholog Compara
Notochord cell developmentdefinition[GO:0060035] silver  
1
  • Ortholog Compara
Notochord formationdefinition[GO:0014028] silver  
1
  • Ortholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
1
  • Ortholog Curator
Osteoclast differentiationdefinition[GO:0030316]  
1
  • Ortholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
4
  • GOC
  • InterPro 2 GO
  • UniProtKB KW
  • EC 2 GO
Positive regulation of establishment of protein localization to plasma membranedefinition[GO:0090004]  
1
  • UniProtKB
Post-anal tail morphogenesisdefinition[GO:0036342] silver  
1
  • Ortholog Compara
Protein kinase B signalingdefinition[GO:0043491]  
1
  • UniProtKB
Regulation of angiogenesisdefinition[GO:0045765]  
1
  • Ortholog Curator
Regulation of blood vessel endothelial cell migrationdefinition[GO:0043535]  
1
  • Ortholog Curator
Regulation of cell adhesion mediated by integrindefinition[GO:0033628]  
1
  • UniProtKB
Regulation of ERK1 and ERK2 cascadedefinition[GO:0070372]  
1
  • UniProtKB
Regulation of lamellipodium assemblydefinition[GO:0010591]  
1
  • UniProtKB
Response to growth factordefinition[GO:0070848]  
1
  • UniProtKB
Skeletal system developmentdefinition[GO:0001501] silver  
1
  • Ortholog Compara
Vasculogenesisdefinition[GO:0001570] silver  
1
  • Ortholog Compara
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
3
  • UniProtKB
  • PROSITE-ProRule
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+1969  
According to Reactome, this protein belongs to the following pathways:
EPH-ephrin mediated repulsion of cells  REACT_264198  
EPH-Ephrin signaling  REACT_264068  
EPHA-mediated growth cone collapse  REACT_264548  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Apoptosis  definition   [KW-0053]
Cell adhesion  definition   [KW-0130]
Differentiation  definition   [KW-0221]
Host-virus interaction  definition   [KW-0945]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPH_receptor_A2
GenomeRNAi: 1969
PRO: PR:P29317
Chemistry
GuidetoPHARMACOLOGY: 1822