EPHA8 - Ephrin type-A receptor 8 - human protein (Function)
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EPHA8 »  Ephrin type-A receptor 8   [ EC ]
Protein also known as:  Tyrosine-protein kinase receptor EEK.
Gene name:  EPHA8
Entry whose protein(s) existence is based on evidence at protein level
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Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
GPI-linked ephrin receptor activitydefinition[GO:0005004]  
  • ISSOrtholog Curator
GO biological process 
Axon guidancedefinition[GO:0007411]  
  • ISSOrtholog Curator
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
  • ISSOrtholog Curator
Neuron projection developmentdefinition[GO:0031175]  
  • ISSOrtholog Curator
Neuron remodelingdefinition[GO:0016322]  
  • ISSOrtholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
  • IEAUniProtKB KW
  • IEAEC 2 GO
  • IEAInterPro 2 GO
Positive regulation of MAPK cascadedefinition[GO:0043410]  
  • ISSOrtholog Curator
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
  • ISSOrtholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
  • ISSOrtholog Curator
Regulation of cell adhesiondefinition[GO:0030155]  
  • ISSOrtholog Curator
Regulation of cell adhesion mediated by integrindefinition[GO:0033628]  
  • ISSOrtholog Curator
Substrate-dependent cell migrationdefinition[GO:0006929]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
More information is available from:
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+2046  


Biological process 
Cell adhesion  definition   [KW-0130]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: EPHA8
GenomeRNAi: 2046
PRO: PR:P29322