EPHA8 - Ephrin type-A receptor 8 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
EPHA8 »  Ephrin type-A receptor 8   [ EC 2.7.10.1 ]
 
Protein also known as:  Tyrosine-protein kinase receptor EEK.
Gene name:  EPHA8
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 41 2
GENE REF ISO

Function

 show evidences
Overview 
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).  
1
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
GPI-linked ephrin receptor activitydefinition[GO:0005004]  
1
  • Ortholog Curator
GO biological process 
Axon guidancedefinition[GO:0007411]  
1
  • Ortholog Curator
Cell adhesiondefinition[GO:0007155]  
1
  • UniProtKB KW
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
1
  • Ortholog Curator
Neuron projection developmentdefinition[GO:0031175]  
1
  • Ortholog Curator
Neuron remodelingdefinition[GO:0016322]  
1
  • Ortholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
3
  • InterPro 2 GO
  • UniProtKB KW
  • EC 2 GO
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • Ortholog Curator
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
1
  • Ortholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
1
  • Ortholog Curator
Regulation of cell adhesiondefinition[GO:0030155]  
1
  • Ortholog Curator
Regulation of cell adhesion mediated by integrindefinition[GO:0033628]  
1
  • Ortholog Curator
Substrate-dependent cell migrationdefinition[GO:0006929]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • UniProtKB
  • PROSITE-ProRule
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+2046  
According to Reactome, this protein belongs to the following pathways:
EPH-ephrin mediated repulsion of cells  REACT_228189  
EPH-Ephrin signaling  REACT_228170  
EPHA-mediated growth cone collapse  REACT_228063  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPHA8
GenomeRNAi: 2046
PRO: PR:P29322
Chemistry
GuidetoPHARMACOLOGY: 1828