EPHB2 - Ephrin type-B receptor 2 - human protein (Function)
 
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EPHB2 »  Ephrin type-B receptor 2   [ EC 2.7.10.1 ]
 
Protein also known as:  Developmentally-regulated Eph-related tyrosine kinase.
Gene name:  EPHB2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 89 3
GENE REF ISO

Function

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Overview 
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Axon guidance receptor activitydefinition[GO:0008046] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • Ortholog Curator
Receptor bindingdefinition[GO:0005102] silver  
1
  • Ortholog Compara
Transmembrane-ephrin receptor activitydefinition[GO:0005005]  
2
  • UniProtKB
  • Ortholog Curator
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • Ortholog Curator
Axon guidancedefinition[GO:0007411]  
1
  • Ortholog Curator
Axonal fasciculationdefinition[GO:0007413]  
1
  • Ortholog Curator
Camera-type eye morphogenesisdefinition[GO:0048593] silver  
1
  • Ortholog Compara
Central nervous system projection neuron axonogenesisdefinition[GO:0021952] silver  
1
  • Ortholog Compara
Commissural neuron axon guidancedefinition[GO:0071679]  
1
  • Ortholog Curator
Corpus callosum developmentdefinition[GO:0022038]  
1
  • Ortholog Curator
Dendritic spine developmentdefinition[GO:0060996]  
1
  • Ortholog Curator
Dendritic spine morphogenesisdefinition[GO:0060997]  
1
  • Ortholog Curator
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
1
  • Ortholog Curator
Inner ear morphogenesisdefinition[GO:0042472]  
1
  • Ortholog Curator
Learningdefinition[GO:0007612] silver  
1
  • Ortholog Compara
Negative regulation of axonogenesisdefinition[GO:0050771] silver  
1
  • Ortholog Compara
Nervous system developmentdefinition[GO:0007399]  
1
  • UniProtKB
Optic nerve morphogenesisdefinition[GO:0021631] silver  
1
  • Ortholog Compara
Palate developmentdefinition[GO:0060021]  
1
  • Ortholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • Ortholog Curator
Phosphorylationdefinition[GO:0016310]  
1
  • Ortholog Curator
Positive regulation of long-term neuronal synaptic plasticitydefinition[GO:0048170] silver  
1
  • Ortholog Compara
Positive regulation of synapse assemblydefinition[GO:0051965]  
1
  • Ortholog Curator
Regulation of body fluid levelsdefinition[GO:0050878]  
1
  • Ortholog Curator
Retinal ganglion cell axon guidancedefinition[GO:0031290] silver  
1
  • Ortholog Compara
Urogenital system developmentdefinition[GO:0001655]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • UniProtKB
  • PROSITE-ProRule
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+2048  
According to Reactome, this protein belongs to the following pathways:
EPH-ephrin mediated repulsion of cells  REACT_228189  
EPH-Ephrin signaling  REACT_228170  
EPHB-mediated forward signaling  REACT_228085  
Ephrin signaling  REACT_228226  
L1CAM interactions  REACT_22205  
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPH_receptor_B2
GenomeRNAi: 2048
PRO: PR:P29323
Chemistry
GuidetoPHARMACOLOGY: 1831