EPHB2 - Ephrin type-B receptor 2 - human protein (Function)
 
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EPHB2 »  Ephrin type-B receptor 2
 
Gene name:  EPHB2
Entry whose protein(s) existence is based on evidence at protein level
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1 88 3
GENE REF ISO

Function

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Overview 
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. Beside axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Axon guidance receptor activitydefinition[GO:0008046] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein tyrosine kinase activitydefinition[GO:0004713]  
  • ISSOrtholog Curator
Receptor bindingdefinition[GO:0005102] silver  
  • IEAOrtholog Compara
Transmembrane-ephrin receptor activitydefinition[GO:0005005]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
GO biological process 
Angiogenesisdefinition[GO:0001525]  
  • ISSOrtholog Curator
Axon guidancedefinition[GO:0007411]  
  • ISSOrtholog Curator
Axonal fasciculationdefinition[GO:0007413]  
  • ISSOrtholog Curator
Camera-type eye morphogenesisdefinition[GO:0048593] silver  
  • IEAOrtholog Compara
Central nervous system projection neuron axonogenesisdefinition[GO:0021952] silver  
  • IEAOrtholog Compara
Commissural neuron axon guidancedefinition[GO:0071679]  
  • ISSOrtholog Curator
Corpus callosum developmentdefinition[GO:0022038]  
  • ISSOrtholog Curator
Dendritic spine developmentdefinition[GO:0060996]  
  • ISSOrtholog Curator
Dendritic spine morphogenesisdefinition[GO:0060997]  
  • ISSOrtholog Curator
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
  • ISSOrtholog Curator
Inner ear morphogenesisdefinition[GO:0042472]  
  • ISSOrtholog Curator
Learningdefinition[GO:0007612] silver  
  • IEAOrtholog Compara
Negative regulation of axonogenesisdefinition[GO:0050771] silver  
  • IEAOrtholog Compara
Nervous system developmentdefinition[GO:0007399]  
1
  • TASUniProtKB
Optic nerve morphogenesisdefinition[GO:0021631] silver  
  • IEAOrtholog Compara
Palate developmentdefinition[GO:0060021]  
  • ISSOrtholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
  • ISSOrtholog Curator
Phosphorylationdefinition[GO:0016310]  
  • ISSOrtholog Curator
Positive regulation of long-term neuronal synaptic plasticitydefinition[GO:0048170] silver  
  • IEAOrtholog Compara
Positive regulation of synapse assemblydefinition[GO:0051965]  
  • ISSOrtholog Curator
Regulation of body fluid levelsdefinition[GO:0050878]  
  • ISSOrtholog Curator
Retinal ganglion cell axon guidancedefinition[GO:0031290] silver  
  • IEAOrtholog Compara
Urogenital system developmentdefinition[GO:0001655]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+2048  
According to Reactome, this protein belongs to the following pathway:
L1CAM interactions  REACT_22205  
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPH_receptor_B2
GenomeRNAi: 2048
PRO: PR:P29323
Chemistry
GuidetoPHARMACOLOGY: 1831