PTPN6 - Tyrosine-protein phosphatase non-receptor type 6 - human protein (Function)
 
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PTPN6 »  Tyrosine-protein phosphatase non-receptor type 6   [ EC 3.1.3.48 ]
 
Protein also known as:  Hematopoietic cell protein-tyrosine phosphatase.
Gene name:  PTPN6
Entry whose protein(s) existence is based on evidence at protein level
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1 228 4
GENE REF ISO

Function

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Overview 
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.  
2
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
36
  • IntAct
  • BHF-UCL
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • UniProtKB
Transmembrane receptor protein tyrosine phosphatase activitydefinition[GO:0005001]  
1
  • UniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • PINC
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • UniProtKB
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • PINC
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • UniProtKB
Negative regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050732]  
1
  • BHF-UCL
Peptidyl-tyrosine dephosphorylationdefinition[GO:0035335]  
3
  • GOC
  • EC 2 GO
  • InterPro 2 GO
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
2
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
1
  • BHF-UCL
Protein dephosphorylationdefinition[GO:0006470]  
1
  • UniProtKB
Regulation of ERK1 and ERK2 cascadedefinition[GO:0070372]  
1
  • UniProtKB
Regulation of G1/S transition of mitotic cell cycledefinition[GO:2000045]  
1
  • BHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.48: Protein tyrosine phosphate + H(2)O protein tyrosine + phosphate.  
2
  • UniProtKB
  • PROSITE-ProRule
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+5777  
B cell receptor signaling pathway  hsa04662+5777  
Jak-STAT signaling pathway  hsa04630+5777  
Leishmaniasis  hsa05140+5777  
Natural killer cell mediated cytotoxicity  hsa04650+5777  
T cell receptor signaling pathway  hsa04660+5777  
According to Reactome, this protein belongs to the following pathways:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  R-HSA-983695  
Costimulation by the CD28 family  R-HSA-388841  
GPVI-mediated activation cascade  R-HSA-114604  
Growth hormone receptor signaling  R-HSA-982772  
Interferon alpha/beta signaling  R-HSA-909733  
Interferon gamma signaling  R-HSA-877300  
Interleukin receptor SHC signaling  R-HSA-912526  
Interleukin-3, 5 and GM-CSF signaling  R-HSA-512988  
PD-1 signaling  R-HSA-389948  
PECAM1 interactions  R-HSA-210990  
Platelet sensitization by LDL  R-HSA-432142  
Regulation of IFNA signaling  R-HSA-912694  
Regulation of IFNG signaling  R-HSA-877312  
Regulation of KIT signaling  R-HSA-1433559  
Signal regulatory protein (SIRP) family interactions  R-HSA-391160  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PTPN6
GenomeRNAi: 5777
PRO: PR:P29350