PTPN6 - Tyrosine-protein phosphatase non-receptor type 6 - human protein (Function)
 
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PTPN6 »  Tyrosine-protein phosphatase non-receptor type 6   [ EC 3.1.3.48 ]
 
Protein also known as:  Hematopoietic cell protein-tyrosine phosphatase.
Gene name:  PTPN6
Entry whose protein(s) existence is based on evidence at protein level
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1 182 4
GENE REF ISO

Function

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Overview 
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.  
1
  • CuratedUniProtKB
GO molecular function 
Phosphotyrosine bindingdefinition[GO:0001784] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
33
  • IPIIntAct
  • IPIBHF-UCL
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
SH2 domain bindingdefinition[GO:0042169] silver  
  • IEAOrtholog Compara
SH3 domain bindingdefinition[GO:0017124] silver  
  • IEAOrtholog Compara
Transmembrane receptor protein tyrosine phosphatase activitydefinition[GO:0005001]  
1
  • IDAUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • TASPINC
B cell receptor signaling pathwaydefinition[GO:0050853] silver  
  • IEAOrtholog Compara
Cell differentiationdefinition[GO:0030154]  
1
  • IDAUniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • IDAUniProtKB
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Natural killer cell mediated cytotoxicitydefinition[GO:0042267] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • NASUniProtKB
Negative regulation of humoral immune response mediated by circulating immunoglobulindefinition[GO:0002924] silver  
  • IEAOrtholog Compara
Negative regulation of MAP kinase activitydefinition[GO:0043407] silver  
  • IEAOrtholog Compara
Negative regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050732]  
1
  • IMPBHF-UCL
Negative regulation of T cell proliferationdefinition[GO:0042130] silver  
  • IEAOrtholog Compara
Negative regulation of T cell receptor signaling pathwaydefinition[GO:0050860] silver  
  • IEAOrtholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
2
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • IMPBHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
1
  • IMPBHF-UCL
Protein dephosphorylationdefinition[GO:0006470]  
1
  • IDAUniProtKB
Regulation of B cell differentiationdefinition[GO:0045577] silver  
  • IEAOrtholog Compara
Regulation of ERK1 and ERK2 cascadedefinition[GO:0070372]  
1
  • IDAUniProtKB
Regulation of G1/S transition of mitotic cell cycledefinition[GO:2000045]  
1
  • IMPBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.48: Protein tyrosine phosphate + H(2)O protein tyrosine + phosphate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+5777  
B cell receptor signaling pathway  hsa04662+5777  
Jak-STAT signaling pathway  hsa04630+5777  
Leishmaniasis  hsa05140+5777  
Natural killer cell mediated cytotoxicity  hsa04650+5777  
T cell receptor signaling pathway  hsa04660+5777  
According to Reactome, this protein belongs to the following pathways:
Cell-Cell communication  REACT_111155  
Hemostasis  REACT_604  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PTPN6
GenomeRNAi: 5777
PRO: PR:P29350