SHC1 - SHC-transforming protein 1 - human protein (Function)
 
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Protein
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References

 
SHC1 »  SHC-transforming protein 1
 
Protein also known as:  Src homology 2 domain-containing-transforming protein C1 (SH2 domain protein C1).
Gene name:  SHC1
Entry whose protein(s) existence is based on evidence at protein level
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1 380 6
GENE REF ISO

Function

 show evidences
Overview 
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF.  
1
  • CuratedUniProtKB
Isoform  p66Shc   Acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.  
1
  • CuratedUniProtKB
Isoforms  p52Shc and p46Shc   Once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals.  
1
  • CuratedUniProtKB
Isoforms  p52Shc and p46Shc   May thus function as initiators of the Ras signaling cascade in various non-neuronal systems.  
1
  • CuratedUniProtKB
Isoform  p66Shc   Does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span.  
1
  • CuratedUniProtKB
GO molecular function 
Ephrin receptor bindingdefinition[GO:0046875]  
1
  • IPIUniProtKB
Epidermal growth factor receptor bindingdefinition[GO:0005154]  
  • ISSOrtholog Curator
Insulin receptor bindingdefinition[GO:0005158]  
1
  • IPIUniProtKB
Insulin-like growth factor receptor bindingdefinition[GO:0005159]  
1
  • IPIUniProtKB
Neurotrophin TRKA receptor bindingdefinition[GO:0005168]  
1
  • IPIUniProtKB
Phospholipid bindingdefinition[GO:0005543]  
1
  • TASUniProtKB
Protein bindingdefinition[GO:0005515]  
36
  • IPIIntAct
  • IPIUniProtKB
Transmembrane receptor protein tyrosine kinase adaptor activitydefinition[GO:0005068]  
1
  • TASUniProtKB
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532] silver  
  • IEAOrtholog Compara
Activation of MAPK activitydefinition[GO:0000187]  
1
  • IDAUniProtKB
Angiogenesisdefinition[GO:0001525] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Insulin receptor signaling pathwaydefinition[GO:0008286]  
  • ISSOrtholog Curator
MAPK cascadedefinition[GO:0000165]  
1
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • NASUniProtKB
Positive regulation of DNA replicationdefinition[GO:0045740]  
  • ISSOrtholog Curator
Regulation of epidermal growth factor-activated receptor activitydefinition[GO:0007176]  
1
  • TASPINC
Regulation of growthdefinition[GO:0040008]  
  • IEAUniProtKB KW
Single organismal cell-cell adhesiondefinition[GO:0016337] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bacterial invasion of epithelial cells  hsa05100+6464  
Chemokine signaling pathway  hsa04062+6464  
Chronic myeloid leukemia  hsa05220+6464  
ErbB signaling pathway  hsa04012+6464  
Focal adhesion  hsa04510+6464  
Glioma  hsa05214+6464  
Insulin signaling pathway  hsa04910+6464  
Natural killer cell mediated cytotoxicity  hsa04650+6464  
Neurotrophin signaling pathway  hsa04722+6464  
According to Reactome, this protein belongs to the following pathways:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  REACT_118700  
DAP12 signaling  REACT_147814  
FCERI mediated Ca+2 mobilization  REACT_163834  
FCERI mediated MAPK activation  REACT_163701  
Integrin alphaIIb beta3 signaling  REACT_15523  
Interleukin receptor SHC signaling  REACT_23891  
Interleukin-2 signaling  REACT_27283  
Interleukin-3, 5 and GM-CSF signaling  REACT_23837  
Role of LAT2/NTAL/LAB on calcium mobilization  REACT_163769  
SHC activation  REACT_1661  
SHC-mediated cascade  REACT_21374  
SHC-mediated signalling  REACT_661  
SHC-related events triggered by IGF1R  REACT_150139  
SHC1 events in EGFR signaling  REACT_12579  
SHC1 events in ERBB2 signaling  REACT_115993  
SHC1 events in ERBB4 signaling  REACT_116005  
Signal attenuation  REACT_508  
Signaling by constitutively active EGFR  REACT_115852  
Signalling to RAS  REACT_12033  
Tie2 Signaling  REACT_12621  
XBP1(S) activates chaperone genes  REACT_18273  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Growth regulation  definition   [KW-0341]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SHC1
GenomeRNAi: 6464
PRO: PR:P29353