SHC1 - SHC-transforming protein 1 - human protein (Function)
 
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Protein
Gene
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SHC1 »  SHC-transforming protein 1
 
Protein also known as:  Src homology 2 domain-containing-transforming protein C1 (SH2 domain protein C1).
Gene name:  SHC1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF.  
1
  • UniProtKB
Isoform  p66Shc   Acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.  
2
  • UniProtKB
Isoforms  p52Shc and p46Shc   Once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals.  
1
  • UniProtKB
Isoforms  p52Shc and p46Shc   May thus function as initiators of the Ras signaling cascade in various non-neuronal systems.  
1
  • UniProtKB
Isoform  p66Shc   Does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span.  
1
  • UniProtKB
GO molecular function 
Ephrin receptor bindingdefinition[GO:0046875]  
1
  • UniProtKB
Epidermal growth factor receptor bindingdefinition[GO:0005154]  
1
  • Ortholog Curator
Insulin receptor bindingdefinition[GO:0005158]  
1
  • UniProtKB
Insulin-like growth factor receptor bindingdefinition[GO:0005159]  
1
  • UniProtKB
Neurotrophin TRKA receptor bindingdefinition[GO:0005168]  
1
  • UniProtKB
Phospholipid bindingdefinition[GO:0005543]  
1
  • UniProtKB
Phosphotyrosine bindingdefinition[GO:0001784] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
40
  • IntAct
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • RefGenome
Protein phosphatase 2A bindingdefinition[GO:0051721] silver  
1
  • Ortholog Compara
Transmembrane receptor protein tyrosine kinase adaptor activitydefinition[GO:0005068]  
1
  • UniProtKB
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532] silver  
1
  • Ortholog Compara
Activation of MAPK activitydefinition[GO:0000187]  
1
  • UniProtKB
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Angiogenesisdefinition[GO:0001525] silver  
1
  • Ortholog Compara
Cellular response to growth factor stimulusdefinition[GO:0071363]  
1
  • UniProtKB
Heart developmentdefinition[GO:0007507] silver  
1
  • Ortholog Compara
Insulin receptor signaling pathwaydefinition[GO:0008286]  
2
  • Ortholog Curator
  • RefGenome
MAPK cascadedefinition[GO:0000165]  
1
  • UniProtKB
Organ regenerationdefinition[GO:0031100] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • UniProtKB
Positive regulation of DNA replicationdefinition[GO:0045740]  
1
  • Ortholog Curator
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
1
  • Ortholog Compara
Positive regulation of vasoconstrictiondefinition[GO:0045907] silver  
1
  • Ortholog Compara
Regulation of epidermal growth factor-activated receptor activitydefinition[GO:0007176]  
1
  • PINC
Regulation of growthdefinition[GO:0040008]  
1
  • UniProtKB KW
Response to glucocorticoiddefinition[GO:0051384] silver  
1
  • Ortholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to nicotinedefinition[GO:0035094] silver  
1
  • Ortholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
1
  • Ortholog Compara
Single organismal cell-cell adhesiondefinition[GO:0016337] silver  
1
  • Ortholog Compara
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bacterial invasion of epithelial cells  hsa05100+6464  
Chemokine signaling pathway  hsa04062+6464  
Chronic myeloid leukemia  hsa05220+6464  
ErbB signaling pathway  hsa04012+6464  
Focal adhesion  hsa04510+6464  
Glioma  hsa05214+6464  
Insulin signaling pathway  hsa04910+6464  
Natural killer cell mediated cytotoxicity  hsa04650+6464  
Neurotrophin signaling pathway  hsa04722+6464  
According to Reactome, this protein belongs to the following pathways:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  R-HSA-983695  
Constitutive Signaling by EGFRvIII  R-HSA-5637810  
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants  R-HSA-1236382  
DAP12 signaling  R-HSA-2424491  
FCERI mediated Ca+2 mobilization  R-HSA-2871809  
FCERI mediated MAPK activation  R-HSA-2871796  
G beta:gamma signalling through PI3Kgamma  R-HSA-392451  
GPVI-mediated activation cascade  R-HSA-114604  
Insulin receptor signalling cascade  R-HSA-74751  
Integrin alphaIIb beta3 signaling  R-HSA-354192  
Interleukin receptor SHC signaling  R-HSA-912526  
Interleukin-2 signaling  R-HSA-451927  
Interleukin-3, 5 and GM-CSF signaling  R-HSA-512988  
RAF/MAP kinase cascade  R-HSA-5673001  
Role of LAT2/NTAL/LAB on calcium mobilization  R-HSA-2730905  
SHC-mediated cascade:FGFR1  R-HSA-5654688  
SHC-mediated cascade:FGFR2  R-HSA-5654699  
SHC-mediated cascade:FGFR3  R-HSA-5654704  
SHC-mediated cascade:FGFR4  R-HSA-5654719  
SHC-related events triggered by IGF1R  R-HSA-2428933  
SHC1 events in EGFR signaling  R-HSA-180336  
SHC1 events in ERBB2 signaling  R-HSA-1250196  
SHC1 events in ERBB4 signaling  R-HSA-1250347  
Signal attenuation  R-HSA-74749  
Signalling to RAS  R-HSA-167044  
Tie2 Signaling  R-HSA-210993  
XBP1(S) activates chaperone genes  R-HSA-381038  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Growth regulation  definition   [KW-0341]
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SHC1
GenomeRNAi: 6464
PRO: PR:P29353