COL4A5 - Collagen alpha-5(IV) chain - human protein (Function)
 
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COL4A5 »  Collagen alpha-5(IV) chain
 
Gene name:  COL4A5
Family name: Type IV collagen
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.  
1
  • UniProtKB
GO molecular function 
Extracellular matrix structural constituentdefinition[GO:0005201] silver  
1
  • InterPro 2 GO
GO biological process 
Neuromuscular junction developmentdefinition[GO:0007528] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+1287  
ECM-receptor interaction  hsa04512+1287  
Focal adhesion  hsa04510+1287  
Pathways in cancer  hsa05200+1287  
Protein digestion and absorption  hsa04974+1287  
Small cell lung cancer  hsa05222+1287  
According to Reactome, this protein belongs to the following pathways:
Anchoring fibril formation  R-HSA-2214320  
Assembly of collagen fibrils and other multimeric structures  R-HSA-2022090  
Collagen biosynthesis and modifying enzymes  R-HSA-1650814  
Collagen degradation  R-HSA-1442490  
ECM proteoglycans  R-HSA-3000178  
Extracellular matrix organization  R-HSA-1474244  
Integrin cell surface interactions  R-HSA-216083  
Laminin interactions  R-HSA-3000157  
NCAM1 interactions  R-HSA-419037  
Non-integrin membrane-ECM interactions  R-HSA-3000171  
Signaling by PDGF  R-HSA-186797  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: COL4A5
GenomeRNAi: 1287
PRO: PR:P29400