COL4A5 - Collagen alpha-5(IV) chain - human protein (Function)
 
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Protein
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References

 
COL4A5 »  Collagen alpha-5(IV) chain
 
Gene name:  COL4A5
Family name: Type IV collagen
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.  
  • CuratedUniProtKB
GO molecular function 
Extracellular matrix structural constituentdefinition[GO:0005201] silver  
  • IEAInterPro 2 GO
GO biological process 
Neuromuscular junction developmentdefinition[GO:0007528] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+1287  
ECM-receptor interaction  hsa04512+1287  
Focal adhesion  hsa04510+1287  
Pathways in cancer  hsa05200+1287  
Protein digestion and absorption  hsa04974+1287  
Small cell lung cancer  hsa05222+1287  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Extracellular matrix organization  REACT_118779  
Signal Transduction  REACT_111102  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: COL4A5
GenomeRNAi: 1287
PRO: PR:P29400