IL12B - Interleukin-12 subunit beta - human protein (Function)
 
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IL12B »  Interleukin-12 subunit beta
 
Gene name:  IL12B
Entry whose protein(s) existence is based on evidence at protein level
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1 227 1
GENE REF ISO

Function

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Overview 
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.  
1
  • CuratedUniProtKB
Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.  
1
  • CuratedUniProtKB
GO molecular function 
Contributes to cytokine activitydefinition[GO:0005125]  
1
  • IDAUniProtKB
Cytokine receptor activitydefinition[GO:0004896] silver  
  • IEAInterPro 2 GO
Contributes to growth factor activitydefinition[GO:0008083]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Interleukin-12 alpha subunit bindingdefinition[GO:0042164]  
1
  • IPIAgBase
Contributes to interleukin-12 receptor bindingdefinition[GO:0005143]  
2
  • TASBHF-UCL
  • TASUniProtKB
Contributes to interleukin-23 receptor bindingdefinition[GO:0045519]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982]  
2
  • IPIAgBase
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
GO biological process 
Cell cycle arrestdefinition[GO:0007050]  
1
  • IDABHF-UCL
Cell migrationdefinition[GO:0016477]  
1
  • IDAUniProtKB
Cellular response to interferon-gammadefinition[GO:0071346] silver  
  • IEAOrtholog Compara
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
  • IEAOrtholog Compara
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
  • IEAInterPro 2 GO
Defense response to Gram-negative bacteriumdefinition[GO:0050829]  
2
  • IDABHF-UCL
Defense response to protozoandefinition[GO:0042832] silver  
  • IEAOrtholog Compara
Defense response to virusdefinition[GO:0051607] silver  
  • IEAOrtholog Compara
Interferon-gamma biosynthetic processdefinition[GO:0042095]  
1
  • TASUniProtKB
Natural killer cell activationdefinition[GO:0030101]  
1
  • IDAUniProtKB
Natural killer cell activation involved in immune responsedefinition[GO:0002323] silver  
  • IEAOrtholog Compara
Negative regulation of growth of symbiont in hostdefinition[GO:0044130] silver  
  • IEAOrtholog Compara
Negative regulation of inflammatory response to antigenic stimulusdefinition[GO:0002862] silver  
  • IEAOrtholog Compara
Negative regulation of interleukin-10 productiondefinition[GO:0032693]  
1
  • IMPBHF-UCL
Negative regulation of interleukin-17 productiondefinition[GO:0032700]  
1
  • IDABHF-UCL
Negative regulation of smooth muscle cell proliferationdefinition[GO:0048662]  
1
  • IDABHF-UCL
Positive regulation of activated T cell proliferationdefinition[GO:0042104]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Positive regulation of activation of JAK2 kinase activitydefinition[GO:0010535]  
1
  • IDABHF-UCL
Positive regulation of cell adhesiondefinition[GO:0045785]  
1
  • IDAUniProtKB
Positive regulation of defense response to virus by hostdefinition[GO:0002230]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Positive regulation of granulocyte macrophage colony-stimulating factor productiondefinition[GO:0032725]  
1
  • IDABHF-UCL
Positive regulation of inflammatory responsedefinition[GO:0050729]  
1
  • ICBHF-UCL
Positive regulation of interferon-gamma biosynthetic processdefinition[GO:0045078]  
1
  • TASUniProtKB
Positive regulation of interferon-gamma productiondefinition[GO:0032729]  
4
  • IDABHF-UCL
  • IDAUniProtKB
Positive regulation of interleukin-10 productiondefinition[GO:0032733]  
2
  • TASBHF-UCL
Positive regulation of interleukin-12 productiondefinition[GO:0032735]  
1
  • IDABHF-UCL
Positive regulation of interleukin-17 productiondefinition[GO:0032740]  
3
  • IDABHF-UCL
Positive regulation of lymphocyte proliferationdefinition[GO:0050671]  
1
  • IDAUniProtKB
Positive regulation of memory T cell differentiationdefinition[GO:0043382]  
  • ISSOrtholog Curator
Positive regulation of mononuclear cell proliferationdefinition[GO:0032946]  
1
  • IMPAgBase
Positive regulation of natural killer cell activationdefinition[GO:0032816]  
2
  • ICBHF-UCL
  • IDAUniProtKB
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetdefinition[GO:0002860]  
1
  • IDAUniProtKB
Positive regulation of natural killer cell proliferationdefinition[GO:0032819]  
1
  • IDABHF-UCL
Positive regulation of NF-kappaB import into nucleusdefinition[GO:0042346]  
1
  • TASBHF-UCL
Positive regulation of NK T cell activationdefinition[GO:0051135]  
2
  • IDABHF-UCL
Positive regulation of NK T cell proliferationdefinition[GO:0051142]  
1
  • IDABHF-UCL
Positive regulation of osteoclast differentiationdefinition[GO:0045672]  
1
  • IDABHF-UCL
Positive regulation of smooth muscle cell apoptotic processdefinition[GO:0034393]  
1
  • IDABHF-UCL
Positive regulation of T cell mediated cytotoxicitydefinition[GO:0001916]  
  • ISSOrtholog Curator
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • IDABHF-UCL
Positive regulation of T-helper 1 type immune responsedefinition[GO:0002827]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Positive regulation of T-helper 17 cell lineage commitmentdefinition[GO:2000330]  
  • ISSOrtholog Curator
Positive regulation of T-helper 17 type immune responsedefinition[GO:2000318]  
  • ISSOrtholog Curator
Positive regulation of tissue remodelingdefinition[GO:0034105]  
1
  • ICBHF-UCL
Positive regulation of tumor necrosis factor productiondefinition[GO:0032760]  
1
  • IMPBHF-UCL
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517]  
1
  • IDABHF-UCL
Positive regulation of tyrosine phosphorylation of Stat4 proteindefinition[GO:0042520]  
3
  • IDABHF-UCL
Positive regulation of tyrosine phosphorylation of Stat5 proteindefinition[GO:0042523]  
1
  • IDABHF-UCL
Regulation of cytokine biosynthetic processdefinition[GO:0042035]  
1
  • TASUniProtKB
Regulation of tyrosine phosphorylation of Stat1 proteindefinition[GO:0042510]  
1
  • IDABHF-UCL
Response to UV-Bdefinition[GO:0010224]  
1
  • IDAUniProtKB
Sensory perception of paindefinition[GO:0019233] silver  
  • IEAOrtholog Compara
Sexual reproductiondefinition[GO:0019953]  
1
  • TASBHF-UCL
T-helper 1 type immune responsedefinition[GO:0042088]  
1
  • TASUniProtKB
T-helper cell differentiationdefinition[GO:0042093]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
African trypanosomiasis  hsa05143+3593  
Allograft rejection  hsa05330+3593  
Amoebiasis  hsa05146+3593  
Chagas disease (American trypanosomiasis)  hsa05142+3593  
Cytokine-cytokine receptor interaction  hsa04060+3593  
Herpes simplex infection  hsa05168+3593  
Influenza A  hsa05164+3593  
Jak-STAT signaling pathway  hsa04630+3593  
Legionellosis  hsa05134+3593  
Leishmaniasis  hsa05140+3593  
Measles  hsa05162+3593  
Pertussis  hsa05133+3593  
RIG-I-like receptor signaling pathway  hsa04622+3593  
Toll-like receptor signaling pathway  hsa04620+3593  
Toxoplasmosis  hsa05145+3593  
Tuberculosis  hsa05152+3593  
Type I diabetes mellitus  hsa04940+3593  
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links