IL12B - Interleukin-12 subunit beta - human protein (Sequence)
 
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Protein
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References

 
IL12B »  Interleukin-12 subunit beta  (IL-12B)
 
Protein also known as:  Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40).
Gene name:  IL12B
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 211 1
GENE REF ISO

Displayed isoform: Iso 1

 
 
Isoform Iso 1   328 aaMass: 37169 Da,  pI: 5.52
MCHQQLVISW FSLVFLASPL VAIWELKKDV YVVELDWYPD APGEMVVLTC DTPEEDGITW TLDQSSEVLG SGKTLTIQVK EFGDAGQYTC HKGGEVLSHS LLLLHKKEDG IWSTDILKDQ KEPKNKTFLR CEAKNYSGRF TCWWLTTIST DLTFSVKSSR GSSDPQGVTC GAATLSAERV RGDNKEYEYS VECQEDSACP AAEESLPIEV MVDAVHKLKY ENYTSSFFIR DIIKPDPPKN LQLKPLKNSR QVEVSWEYPD TWSTPHSYFS LTFCVQVQGK SKREKKDRVF TDKTSATVIC RKNASISVRA QDRYYSSSWS EWASVPCS

Sequence

 show evidences
PTM 
Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Polymorphism  definition   [KW-0621]
Domain 
Immunoglobulin domain  definition   [KW-0393]
Signal  definition   [KW-0732]
PTM 
Disulfide bond  definition   [KW-1015]
Glycoprotein  definition   [KW-0325]
Technical term 
Direct protein sequencing  definition   [KW-0903]
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 2.60.40.10
InterPro: IPR003530 [ Hematopoietin rcpt L F3 CS ]
InterPro: IPR019482 [ IL-12 beta cen-dom ]
InterPro: IPR007110 [ Ig-like dom ]
InterPro: IPR013783 [ Ig-like fold ]
InterPro: IPR015528 [ IL-12 beta ]
InterPro: IPR003598 [ Ig sub2 ]
InterPro: IPR003961 [ Fibronectin type3 ]
PANTHER: PTHR11321 [ PTHR11321 ]
Pfam: PF10420 [ IL12p40 C ]
PIRSF: PIRSF038007 [ IL 12 beta ]
PRINTS: PR01928 [ INTRLEUKN12B ]
PROSITE: PS50835 [ IG LIKE ]
PROSITE: PS01354 [ HEMATOPO REC L F3 ]
PROSITE: PS50853 [ FN3 ]
SMART: SM00408 [ IGc2 ]
SUPFAM: SSF49265 [ SSF49265 ]
Genome annotation databases
Ensembl: Transcript: ENST00000231228;  Protein: ENSP00000231228;  Gene: ENSG00000113302.
KEGG: hsa:3593
UCSC: uc003lxr.1
Organism-specific databases
MGI: MGI:96540 [ Il12b ]
Other
EvolutionaryTrace: P29460
PMAP-CutDB: P29460
PTM databases
PhosphoSite: P29460
UniCarbKB: P29460
Phylogenomic databases
eggNOG: NOG45642
HOGENOM: HOG000113027
HOVERGEN: HBG052094
InParanoid: P29460
KO: K05425
OMA: WSTPHSY
OrthoDB: EOG7TBC2K
PhylomeDB: P29460
Sequence databases
CCDS: CCDS4346.1 [ P29460-1 ]
EMBL: mRNA:  BC067501 . Translation:  AAH67501.1 .
EMBL: mRNA:  BC074723 . Translation:  AAH74723.1 .
EMBL: mRNA:  BC067500 . Translation:  AAH67500.1 .
EMBL: Genomic DNA:  AF512686 . Translation:  AAM34792.1 .
EMBL: mRNA:  AF180563 . Translation:  AAD56386.1 .
EMBL: mRNA:  BC067499 . Translation:  AAH67499.1 .
EMBL: Genomic DNA:  AY008847 . Translation:  AAG32620.1 .
EMBL: mRNA:  M65290 . Translation:  AAA59938.1 .
EMBL: mRNA:  M65272 . Translation:  AAA35695.1 .
EMBL: mRNA:  BC067502 . Translation:  AAH67502.1 .
EMBL: mRNA:  BC067498 . Translation:  AAH67498.1 .
IPI: IPI00021798
PIR: A38957
RefSeq: Protein:  NP_002178.2. Nucleotide sequence:  NM_002187.2.
UniProtKB: P29460 [ IL12B ]
Protocols and materials databases
DNASU: 3593