CASP1 - Caspase-1 - human protein (Function)
 
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CASP1 »  Caspase-1   [ EC 3.4.22.36 ]  (CASP-1)
 
Protein also known as:  Interleukin-1 beta-converting enzyme (ICE). Cleaved into:  Caspase-1 subunit p10; Caspase-1 subunit p20.
Gene name:  CASP1
Family name: Peptidase C14A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 139 5
GENE REF ISO

Function

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Overview 
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.  
2
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activator activity involved in apoptotic processdefinition[GO:0008656]  
1
  • TASPINC
Cysteine-type endopeptidase activitydefinition[GO:0004197] silver  
  • IBARefGenome
Endopeptidase activitydefinition[GO:0004175]  
1
  • IDAParkinsonsUK-UCL
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • TASGOC
Apoptotic processdefinition[GO:0006915]  
1
  • TASPINC
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • IEPUniProtKB
Cellular response to organic substancedefinition[GO:0071310]  
1
  • IDAMGI
Execution phase of apoptosisdefinition[GO:0097194] silver  
  • IBARefGenome
Interleukin-1 beta productiondefinition[GO:0032611] silver  
  • IEAOrtholog Compara
Membrane hyperpolarizationdefinition[GO:0060081] silver  
  • IEAOrtholog Compara
Mitochondrial depolarizationdefinition[GO:0051882] silver  
  • IEAOrtholog Compara
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IEPUniProtKB
Positive regulation of interleukin-1 alpha secretiondefinition[GO:0050717] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-1 beta secretiondefinition[GO:0050718] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
2
  • IDAParkinsonsUK-UCL
  • IDAUniProtKB
Pyroptosisdefinition[GO:0070269] silver  
  • IEAOrtholog Compara
Regulation of inflammatory responsedefinition[GO:0050727] silver  
  • IBARefGenome
Response to ATPdefinition[GO:0033198] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.36: Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.  
  • CuratedUniProtKB
It is regulated in the following manner
Specifically inhibited by the cowpox virus Crma protein.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amyotrophic lateral sclerosis (ALS)  hsa05014+834  
Cytosolic DNA-sensing pathway  hsa04623+834  
Influenza A  hsa05164+834  
Legionellosis  hsa05134+834  
NOD-like receptor signaling pathway  hsa04621+834  
Pertussis  hsa05133+834  
Salmonella infection  hsa05132+834  
According to Reactome, this protein belongs to the following pathways:
Interleukin-1 processing  REACT_23950  
NOD1/2 Signaling Pathway  REACT_75776  
The AIM2 inflammasome  REACT_75777  
The IPAF inflammasome  REACT_75892  
The NLRP3 inflammasome  REACT_75808  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P29466
Other
GeneWiki: Caspase_1
GenomeRNAi: 834
PRO: PR:P29466
Chemistry
GuidetoPHARMACOLOGY: 1617