NOS1 - Nitric oxide synthase, brain - human protein (Function)
 
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NOS1 »  Nitric oxide synthase, brain   [ EC 1.14.13.39 ]
 
Protein also known as:  Peptidyl-cysteine S-nitrosylase NOS1.
Gene name:  NOS1
Family name: NOS
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.  
1
  • UniProtKB
GO molecular function 
Arginine bindingdefinition[GO:0034618]  
1
  • BHF-UCL
Cadmium ion bindingdefinition[GO:0046870]  
1
  • Ortholog Curator
Calmodulin bindingdefinition[GO:0005516]  
1
  • UniProtKB KW
Flavin adenine dinucleotide bindingdefinition[GO:0050660]  
1
  • Ortholog Curator
FMN bindingdefinition[GO:0010181]  
1
  • Ortholog Curator
Heme bindingdefinition[GO:0020037]  
1
  • Ortholog Curator
Ion channel bindingdefinition[GO:0044325]  
1
  • Ortholog Curator
Iron ion bindingdefinition[GO:0005506] silver  
1
  • InterPro 2 GO
NADP bindingdefinition[GO:0050661]  
1
  • Ortholog Curator
NADPH-hemoprotein reductase activitydefinition[GO:0003958]  
1
  • RefGenome
Nitric-oxide synthase activitydefinition[GO:0004517]  
3
  • BHF-UCL
  • Ortholog Curator
  • RefGenome
Oxidoreductase activitydefinition[GO:0016491]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
  • UniProtKB
Scaffold protein bindingdefinition[GO:0097110]  
1
  • Ortholog Curator
Sodium channel regulator activitydefinition[GO:0017080]  
1
  • Ortholog Curator
Tetrahydrobiopterin bindingdefinition[GO:0034617]  
1
  • BHF-UCL
GO biological process 
Arginine catabolic processdefinition[GO:0006527]  
1
  • BHF-UCL
Cellular response to growth factor stimulusdefinition[GO:0071363]  
1
  • Ortholog Curator
Exogenous drug catabolic processdefinition[GO:0042738]  
1
  • Ortholog Curator
Multicellular organismal response to stressdefinition[GO:0033555]  
1
  • BHF-UCL
Myoblast fusiondefinition[GO:0007520]  
1
  • BHF-UCL
Negative regulation of blood pressuredefinition[GO:0045776]  
1
  • RefGenome
Negative regulation of calcium ion transportdefinition[GO:0051926]  
1
  • Ortholog Curator
Negative regulation of calcium ion transport into cytosoldefinition[GO:0010523]  
1
  • BHF-UCL
Negative regulation of hydrolase activitydefinition[GO:0051346]  
1
  • Ortholog Curator
Negative regulation of potassium ion transportdefinition[GO:0043267]  
1
  • Ortholog Curator
Negative regulation of serotonin uptakedefinition[GO:0051612]  
1
  • Ortholog Curator
Neurotransmitter biosynthetic processdefinition[GO:0042136]  
1
  • BHF-UCL
Nitric oxide biosynthetic processdefinition[GO:0006809]  
2
  • BHF-UCL
  • RefGenome
Nitric oxide mediated signal transductiondefinition[GO:0007263]  
1
  • RefGenome
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB KW
Peptidyl-cysteine S-nitrosylationdefinition[GO:0018119]  
1
  • Ortholog Curator
Positive regulation of guanylate cyclase activitydefinition[GO:0031284]  
1
  • RefGenome
Positive regulation of histone acetylationdefinition[GO:0035066]  
1
  • Ortholog Curator
Positive regulation of sodium ion transmembrane transportdefinition[GO:1902307]  
1
  • Ortholog Curator
Positive regulation of the force of heart contractiondefinition[GO:0098735]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • Ortholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • Ortholog Curator
Positive regulation of vasodilationdefinition[GO:0045909]  
2
  • BHF-UCL
Regulation of cardiac muscle contractiondefinition[GO:0055117]  
1
  • BHF-UCL
Regulation of sodium ion transportdefinition[GO:0002028]  
1
  • Ortholog Curator
Response to heatdefinition[GO:0009408]  
1
  • BHF-UCL
Response to hypoxiadefinition[GO:0001666]  
1
  • BHF-UCL
Striated muscle contractiondefinition[GO:0006941]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.14.13.39: 2 L-arginine + 3 NADPH + 4 O(2) 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O.  
1
  • UniProtKB
EC 1.14.13.39: 2 L-arginine + 3 NADPH + 4 O(2) 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O.  
1
  • UniProtKB
It requires the following cofactors
 FAD : Binds 1 FAD.  
1
  • UniProtKB
 FMN : Binds 1 FMN.  
1
  • UniProtKB
 5,6,7,8-tetrahydrobiopterin : Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.  
1
  • UniProtKB
 heme  
1
  • UniProtKB
It is regulated in the following manner
Stimulated by calcium/calmodulin. Inhibited by n-Nos-inhibiting protein (PIN) which may prevent the dimerization of the protein. Inhibited by NOSIP.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+4842  
Amyotrophic lateral sclerosis (ALS)  hsa05014+4842  
Arginine and proline metabolism  hsa00330+4842  
Calcium signaling pathway  hsa04020+4842  
Long-term depression  hsa04730+4842  
Metabolic pathways  hsa01100+4842  
Phagosome  hsa04145+4842  
Salivary secretion  hsa04970+4842  
According to Reactome, this protein belongs to the following pathways:
Nitric oxide stimulates guanylate cyclase  REACT_23862  
Phagosomal maturation (early endosomal stage)  REACT_121256  
 
More information is available from:
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: NOS1
GenomeRNAi: 4842
PRO: PR:P29475
Chemistry
GuidetoPHARMACOLOGY: 1251