SERPINA4 - Kallistatin - human protein (Function)
 
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SERPINA4 »  Kallistatin
 
Protein also known as:  Peptidase inhibitor 4 (PI-4).
Gene name:  SERPINA4
Family name: Serpin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.  
1
  • CuratedUniProtKB
GO molecular function 
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867] silver  
  • IBARefGenome
GO biological process 
Negative regulation of endopeptidase activitydefinition[GO:0010951] silver  
  • IBARefGenome
Regulation of proteolysisdefinition[GO:0030162] silver  
  • IBARefGenome
Enzymatic activity 
 
More information is available from:
Note 
Heparin blocks kallistatin's complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikrein's activity.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Protease inhibitor  definition   [KW-0646]
Serine protease inhibitor  definition   [KW-0722]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SERPINA4
GenomeRNAi: 5267
PRO: PR:P29622