CD40LG - CD40 ligand - human protein (Function)
 
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CD40LG »  CD40 ligand  (CD40-L)
 
Protein also known as:  Tumor necrosis factor ligand superfamily member 5; CD antigen CD154. Cleaved into:  CD40 ligand, membrane form; CD40 ligand, soluble form.
Gene name:  CD40LG
Family name: Tumor necrosis factor
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.  
1
  • CuratedUniProtKB
Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.  
1
  • CuratedUniProtKB
GO molecular function 
CD40 receptor bindingdefinition[GO:0005174]  
1
  • IPIUniProtKB
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Tumor necrosis factor receptor bindingdefinition[GO:0005164] silver  
  • IEAInterPro 2 GO
GO biological process 
B cell differentiationdefinition[GO:0030183] silver  
  • IEAOrtholog Compara
B cell proliferationdefinition[GO:0042100]  
1
  • IDAUniProtKB
Immunoglobulin secretiondefinition[GO:0048305] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954]  
1
  • IDAUniProtKB
Isotype switchingdefinition[GO:0045190]  
  • ISSOrtholog Curator
Leukocyte cell-cell adhesiondefinition[GO:0007159]  
1
  • NASUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAUniProtKB
Platelet activationdefinition[GO:0030168]  
1
  • IDAUniProtKB
Positive regulation of endothelial cell apoptotic processdefinition[GO:2000353]  
1
  • IDABHF-UCL
Positive regulation of interleukin-12 productiondefinition[GO:0032735]  
1
  • IDAUniProtKB
Regulation of immunoglobulin secretiondefinition[GO:0051023] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Allograft rejection  hsa05330+959  
Asthma  hsa05310+959  
Autoimmune thyroid disease  hsa05320+959  
Cell adhesion molecules (CAMs)  hsa04514+959  
Cytokine-cytokine receptor interaction  hsa04060+959  
Intestinal immune network for IgA production  hsa04672+959  
Malaria  hsa05144+959  
Primary immunodeficiency  hsa05340+959  
Systemic lupus erythematosus  hsa05322+959  
T cell receptor signaling pathway  hsa04660+959  
Toxoplasmosis  hsa05145+959  
Viral myocarditis  hsa05416+959  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD154
GenomeRNAi: 959
PRO: PR:P29965