AQP1 - Aquaporin-1 - human protein (Function)
 
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AQP1 »  Aquaporin-1  (AQP-1)
 
Protein also known as:  Water channel protein for red blood cells and kidney proximal tubule.
Gene name:  AQP1
Entry whose protein(s) existence is based on evidence at protein level
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1 85 4
GENE REF ISO

Function

 show evidences
Overview 
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.  
2
  • UniProtKB
According to TCDB this is a transporter from family:
the major intrinsic protein (mip) family  1.A.8.8.1  
GO molecular function 
Ammonium transmembrane transporter activitydefinition[GO:0008519]  
1
  • UniProtKB
Carbon dioxide transmembrane transporter activitydefinition[GO:0035379]  
1
  • UniProtKB
Ephrin receptor bindingdefinition[GO:0046875] silver  
1
  • Ortholog Compara
Glycerol channel activitydefinition[GO:0015254]  
1
  • RefGenome
Glycerol transmembrane transporter activitydefinition[GO:0015168]  
2
  • UniProtKB
Intracellular cGMP activated cation channel activitydefinition[GO:0005223]  
1
  • UniProtKB
Nitric oxide transmembrane transporter activitydefinition[GO:0030184]  
1
  • UniProtKB
Potassium channel activitydefinition[GO:0005267]  
1
  • UniProtKB
Potassium ion transmembrane transporter activitydefinition[GO:0015079]  
1
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
  • UniProtKB
Transmembrane transporter activitydefinition[GO:0022857]  
1
  • UniProtKB
Water channel activitydefinition[GO:0015250]  
2
  • UniProtKB
Water transmembrane transporter activitydefinition[GO:0005372]  
9
  • UniProtKB
GO biological process 
Ammonium transmembrane transportdefinition[GO:0072488]  
1
  • GOC
Ammonium transportdefinition[GO:0015696]  
2
  • UniProtKB
Camera-type eye morphogenesisdefinition[GO:0048593] silver  
1
  • Ortholog Compara
Carbon dioxide transmembrane transportdefinition[GO:0035378]  
1
  • UniProtKB
Carbon dioxide transportdefinition[GO:0015670]  
3
  • UniProtKB
Cation transmembrane transportdefinition[GO:0098655]  
1
  • GOC
Cell volume homeostasisdefinition[GO:0006884]  
1
  • UniProtKB
Cellular homeostasisdefinition[GO:0019725]  
1
  • UniProtKB
Cellular hyperosmotic responsedefinition[GO:0071474]  
1
  • UniProtKB
Cellular response to cAMPdefinition[GO:0071320]  
2
  • UniProtKB
Cellular response to copper iondefinition[GO:0071280]  
2
  • UniProtKB
Cellular response to dexamethasone stimulusdefinition[GO:0071549]  
1
  • UniProtKB
Cellular response to hydrogen peroxidedefinition[GO:0070301]  
1
  • UniProtKB
Cellular response to hypoxiadefinition[GO:0071456]  
1
  • UniProtKB
Cellular response to inorganic substancedefinition[GO:0071241]  
1
  • UniProtKB
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • UniProtKB
Cellular response to mercury iondefinition[GO:0071288]  
5
  • UniProtKB
Cellular response to nitric oxidedefinition[GO:0071732]  
1
  • UniProtKB
Cellular response to retinoic aciddefinition[GO:0071300]  
2
  • UniProtKB
Cellular response to salt stressdefinition[GO:0071472]  
1
  • UniProtKB
Cellular response to stressdefinition[GO:0033554]  
1
  • UniProtKB
Cellular response to UVdefinition[GO:0034644]  
1
  • UniProtKB
Cellular water homeostasisdefinition[GO:0009992]  
1
  • RefGenome
Cerebrospinal fluid secretiondefinition[GO:0033326]  
1
  • UniProtKB
cGMP biosynthetic processdefinition[GO:0006182]  
1
  • UniProtKB
Corticotropin secretiondefinition[GO:0051458] silver  
1
  • Ortholog Compara
Establishment or maintenance of actin cytoskeleton polaritydefinition[GO:0030950]  
1
  • UniProtKB
Glomerular filtrationdefinition[GO:0003094] silver  
1
  • Ortholog Compara
Glycerol transportdefinition[GO:0015793]  
2
  • UniProtKB
Hyperosmotic salinity responsedefinition[GO:0042538] silver  
1
  • Ortholog Compara
Lateral ventricle developmentdefinition[GO:0021670]  
1
  • UniProtKB
Lipid digestiondefinition[GO:0044241] silver  
1
  • Ortholog Compara
Maintenance of symbiont-containing vacuole by hostdefinition[GO:0085018]  
1
  • UniProtKB
Metanephric descending thin limb developmentdefinition[GO:0072220] silver  
1
  • Ortholog Compara
Metanephric glomerulus vasculature developmentdefinition[GO:0072239] silver  
1
  • Ortholog Compara
Metanephric proximal convoluted tubule segment 2 developmentdefinition[GO:0072232] silver  
1
  • Ortholog Compara
Metanephric proximal straight tubule developmentdefinition[GO:0072230] silver  
1
  • Ortholog Compara
Multicellular organismal water homeostasisdefinition[GO:0050891]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154]  
1
  • UniProtKB
Nitric oxide transportdefinition[GO:0030185]  
1
  • UniProtKB
Odontogenesisdefinition[GO:0042476]  
1
  • UniProtKB
Pancreatic juice secretiondefinition[GO:0030157]  
1
  • UniProtKB
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • UniProtKB
Positive regulation of epithelial cell migrationdefinition[GO:0010634] silver  
1
  • Ortholog Compara
Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
1
  • UniProtKB
Positive regulation of lamellipodium assemblydefinition[GO:0010592] silver  
1
  • Ortholog Compara
Positive regulation of saliva secretiondefinition[GO:0046878]  
2
  • UniProtKB
Potassium ion transmembrane transportdefinition[GO:0071805]  
3
  • GOC
  • Ortholog Curator
  • Ortholog Compara
Potassium ion transportdefinition[GO:0006813]  
1
  • Ortholog Curator
Renal water absorptiondefinition[GO:0070295] silver  
1
  • Ortholog Compara
Renal water transportdefinition[GO:0003097]  
1
  • UniProtKB
Response to drugdefinition[GO:0042493]  
1
  • UniProtKB
Response to estrogendefinition[GO:0043627] silver  
1
  • Ortholog Compara
Secretory granule organizationdefinition[GO:0033363] silver  
1
  • Ortholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
1
  • Ortholog Compara
Transepithelial water transportdefinition[GO:0035377]  
1
  • UniProtKB
Water transportdefinition[GO:0006833]  
9
  • UniProtKB
Wound healingdefinition[GO:0042060] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+358  
Proximal tubule bicarbonate reclamation  hsa04964+358  
According to Reactome, this protein belongs to the following pathways:
Erythrocytes take up carbon dioxide and release oxygen  REACT_121329  
Erythrocytes take up oxygen and release carbon dioxide  REACT_121380  
Passive transport by Aquaporins  REACT_23826  
Vasopressin regulates renal water homeostasis via Aquaporins  REACT_24023  
Note 
Pharmacologically inhibited by submillimolar concentrations of mercury.  
1
  • UniProtKB
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Molecular function 
Blood group antigen  definition   [KW-0095]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Aquaporin_1
GenomeRNAi: 358
PRO: PR:P29972
Chemistry
GuidetoPHARMACOLOGY: 688