AQP1 - Aquaporin-1 - human protein (Function)
 
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AQP1 »  Aquaporin-1  (AQP-1)
 
Protein also known as:  Water channel protein for red blood cells and kidney proximal tubule.
Gene name:  AQP1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 76 4
GENE REF ISO

Function

 show evidences
Overview 
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major intrinsic protein (mip) family  1.A.8.8.1  
GO molecular function 
Ammonia transmembrane transporter activitydefinition[GO:0051739]  
1
  • IDAUniProtKB
Carbon dioxide transmembrane transporter activitydefinition[GO:0035379]  
1
  • IDAUniProtKB
Glycerol transmembrane transporter activitydefinition[GO:0015168]  
2
  • IDAUniProtKB
Intracellular cGMP activated cation channel activitydefinition[GO:0005223]  
1
  • IDAUniProtKB
Nitric oxide transmembrane transporter activitydefinition[GO:0030184]  
1
  • IDAUniProtKB
Potassium channel activitydefinition[GO:0005267]  
1
  • IMPUniProtKB
Potassium ion transmembrane transporter activitydefinition[GO:0015079]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Transmembrane transporter activitydefinition[GO:0022857]  
1
  • IDAUniProtKB
Water channel activitydefinition[GO:0015250]  
2
  • IMPUniProtKB
Water transmembrane transporter activitydefinition[GO:0005372]  
9
  • IDAUniProtKB
GO biological process 
Ammonium transportdefinition[GO:0015696]  
2
  • IDAUniProtKB
Carbohydrate transmembrane transportdefinition[GO:0034219]  
2
  • IDAGOC
Carbon dioxide transmembrane transportdefinition[GO:0035378]  
1
  • IDAUniProtKB
Carbon dioxide transportdefinition[GO:0015670]  
3
  • IDAUniProtKB
Cell volume homeostasisdefinition[GO:0006884]  
1
  • IMPUniProtKB
Cellular homeostasisdefinition[GO:0019725]  
1
  • IDAUniProtKB
Cellular hyperosmotic responsedefinition[GO:0071474]  
1
  • IMPUniProtKB
Cellular response to cAMPdefinition[GO:0071320]  
2
  • IDAUniProtKB
Cellular response to copper iondefinition[GO:0071280]  
2
  • IDAUniProtKB
Cellular response to dexamethasone stimulusdefinition[GO:0071549]  
1
  • IDAUniProtKB
Cellular response to hydrogen peroxidedefinition[GO:0070301]  
1
  • IDAUniProtKB
Cellular response to hypoxiadefinition[GO:0071456]  
1
  • IDAUniProtKB
Cellular response to inorganic substancedefinition[GO:0071241]  
1
  • IDAUniProtKB
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • IDAUniProtKB
Cellular response to mercury iondefinition[GO:0071288]  
5
  • IDAUniProtKB
Cellular response to nitric oxidedefinition[GO:0071732]  
1
  • IDAUniProtKB
Cellular response to retinoic aciddefinition[GO:0071300]  
2
  • IDAUniProtKB
Cellular response to salt stressdefinition[GO:0071472]  
1
  • IDAUniProtKB
Cellular response to stressdefinition[GO:0033554]  
1
  • IDAUniProtKB
Cellular response to UVdefinition[GO:0034644]  
1
  • IDAUniProtKB
Cerebrospinal fluid secretiondefinition[GO:0033326]  
1
  • IEPUniProtKB
cGMP biosynthetic processdefinition[GO:0006182]  
1
  • IDAUniProtKB
Establishment or maintenance of actin cytoskeleton polaritydefinition[GO:0030950]  
1
  • IMPUniProtKB
Glycerol transportdefinition[GO:0015793]  
2
  • IDAUniProtKB
Ion transmembrane transportdefinition[GO:0034220]  
2
  • IDAGOC
  • ISSOrtholog Curator
Lateral ventricle developmentdefinition[GO:0021670]  
1
  • IEPUniProtKB
Maintenance of symbiont-containing vacuole by hostdefinition[GO:0085018]  
1
  • IMPUniProtKB
Multicellular organismal water homeostasisdefinition[GO:0050891]  
1
  • IEPUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAUniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154]  
1
  • IMPUniProtKB
Nitric oxide transportdefinition[GO:0030185]  
1
  • IDAUniProtKB
Odontogenesisdefinition[GO:0042476]  
1
  • IEPUniProtKB
Pancreatic juice secretiondefinition[GO:0030157]  
1
  • IEPUniProtKB
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • IMPUniProtKB
Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
1
  • IDAUniProtKB
Positive regulation of saliva secretiondefinition[GO:0046878]  
2
  • IMPUniProtKB
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • IMPGOC
  • ISSOrtholog Curator
Potassium ion transportdefinition[GO:0006813]  
  • ISSOrtholog Curator
Renal water transportdefinition[GO:0003097]  
1
  • IDAUniProtKB
Response to drugdefinition[GO:0042493]  
1
  • IDAUniProtKB
Transepithelial water transportdefinition[GO:0035377]  
1
  • IDAUniProtKB
Water transportdefinition[GO:0006833]  
9
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+358  
Proximal tubule bicarbonate reclamation  hsa04964+358  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Transmembrane transport of small molecules  REACT_15518  
Note 
Pharmacologically inhibited by submillimolar concentrations of mercury.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Molecular function 
Blood group antigen  definition   [KW-0095]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Aquaporin_1
GenomeRNAi: 358
PRO: PR:P29972
Chemistry
GuidetoPHARMACOLOGY: 688