CNGA1 - cGMP-gated cation channel alpha-1 - human protein (Function)
 
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Protein
Gene
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CNGA1 »  cGMP-gated cation channel alpha-1
 
Protein also known as:  Rod photoreceptor cGMP-gated channel subunit alpha.
Gene name:  CNGA1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.5.3  
GO molecular function 
cGMP bindingdefinition[GO:0030553]  
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  • RefGenome
Intracellular cAMP activated cation channel activitydefinition[GO:0005222]  
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  • RefGenome
Intracellular cGMP activated cation channel activitydefinition[GO:0005223]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Voltage-gated potassium channel activitydefinition[GO:0005249]  
1
  • RefGenome
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • RefGenome
Regulation of membrane potentialdefinition[GO:0042391]  
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  • RefGenome
Transportdefinition[GO:0006810]  
1
  • PINC
Visual perceptiondefinition[GO:0007601]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Phototransduction  hsa04744+1259  
According to Reactome, this protein belongs to the following pathways:
Activation of the phototransduction cascade  REACT_163932  
Inactivation, recovery and regulation of the phototransduction cascade  REACT_163919  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sensory transduction  definition   [KW-0716]
Transport  definition   [KW-0813]
Vision  definition   [KW-0844]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cyclic_nucleotide-gated_channel_alpha_1
GenomeRNAi: 1259
PRO: PR:P29973
Chemistry
GuidetoPHARMACOLOGY: 394