GNA11 - Guanine nucleotide-binding protein subunit alpha-11 - human protein (Function)
 
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GNA11 »  Guanine nucleotide-binding protein subunit alpha-11  (G alpha-11)
 
Protein also known as:  Guanine nucleotide-binding protein G(y) subunit alpha.
Gene name:  GNA11
Family name: G-alpha » G(q)
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.  
  • CuratedUniProtKB
GO molecular function 
G-protein beta/gamma-subunit complex bindingdefinition[GO:0031683] silver  
  • IBARefGenome
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
GTPase activitydefinition[GO:0003924] silver  
  • IBARefGenome
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Signal transducer activitydefinition[GO:0004871] silver  
  • IBARefGenome
Type 2A serotonin receptor bindingdefinition[GO:0031826] silver  
  • IBARefGenome
GO biological process 
Action potentialdefinition[GO:0001508] silver  
  • IBARefGenome
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188] silver  
  • IBARefGenome
Developmental pigmentationdefinition[GO:0048066] silver  
  • IEAOrtholog Compara
GTP catabolic processdefinition[GO:0006184] silver  
  • IEAInterPro 2 GO
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Phospholipase C-activating dopamine receptor signaling pathwaydefinition[GO:0060158] silver  
  • IBARefGenome
Regulation of melanocyte differentiationdefinition[GO:0045634] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Skeletal system developmentdefinition[GO:0001501] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+2767  
Calcium signaling pathway  hsa04020+2767  
Chagas disease (American trypanosomiasis)  hsa05142+2767  
Cholinergic synapse  hsa04725+2767  
Gap junction  hsa04540+2767  
GnRH signaling pathway  hsa04912+2767  
Long-term depression  hsa04730+2767  
Vascular smooth muscle contraction  hsa04270+2767  
According to Reactome, this protein belongs to the following pathways:
Acetylcholine regulates insulin secretion  REACT_18405  
ADP signalling through P2Y purinoceptor 1  REACT_19140  
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion  REACT_19193  
G alpha (q) signalling events  REACT_18283  
Thrombin signalling through proteinase activated receptors (PARs)  REACT_21384  
Thromboxane signalling through TP receptor  REACT_20647  
 

Keywords

Molecular function 
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GNA11
GenomeRNAi: 2767
PRO: PR:P29992