PRDX5 - Peroxiredoxin-5, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
PRDX5 »  Peroxiredoxin-5, mitochondrial   [ EC 1.11.1.15 ]
 
Protein also known as:  Peroxisomal antioxidant enzyme.
Gene name:  PRDX5
Family name: Peroxiredoxin 2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 57 4
GENE REF ISO

Function

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Overview 
Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.  
  • CuratedUniProtKB
GO molecular function 
Isoform  Cytoplasmic+peroxisomal   Antioxidant activitydefinition[GO:0016209]  
1
  • IDAUniProtKB
Cysteine-type endopeptidase inhibitor activity involved in apoptotic processdefinition[GO:0043027]  
1
  • IMPUniProtKB
Peroxidase activitydefinition[GO:0004601]  
1
  • IDAUniProtKB
Peroxiredoxin activitydefinition[GO:0051920]  
1
  • IDAUniProtKB
  • IEAEC 2 GO
Isoform  Cytoplasmic+peroxisomal   Peroxynitrite reductase activitydefinition[GO:0072541]  
1
  • IDAUniProtKB
Protein dimerization activitydefinition[GO:0046983]  
2
  • IDAUniProtKB
Receptor bindingdefinition[GO:0005102]  
2
  • IPIUniProtKB
RNA polymerase III regulatory region DNA bindingdefinition[GO:0001016]  
1
  • IDAUniProtKB
GO biological process 
Cellular response to reactive oxygen speciesdefinition[GO:0034614]  
1
  • IMPUniProtKB
Isoform  Cytoplasmic+peroxisomal   Hydrogen peroxide catabolic processdefinition[GO:0042744]  
1
  • IDAUniProtKB
Inflammatory responsedefinition[GO:0006954]  
1
  • TASUniProtKB
Isoform  Cytoplasmic+peroxisomal   NADPH oxidationdefinition[GO:0070995]  
1
  • IDAUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154]  
1
  • IMPGOC
Isoform  Cytoplasmic+peroxisomal   Negative regulation of oxidoreductase activitydefinition[GO:0051354]  
1
  • IDAUniProtKB
Negative regulation of transcription from RNA polymerase III promoterdefinition[GO:0016480]  
1
  • IDAUniProtKB
Isoform  Cytoplasmic+peroxisomal   Positive regulation of collagen biosynthetic processdefinition[GO:0032967]  
1
  • IDAUniProtKB
Isoform  Cytoplasmic+peroxisomal   Reactive nitrogen species metabolic processdefinition[GO:2001057]  
1
  • IDAUniProtKB
Isoform  Cytoplasmic+peroxisomal   Regulation of apoptosis involved in tissue homeostasisdefinition[GO:0060785]  
1
  • IDAUniProtKB
Regulation of RNA biosynthetic processdefinition[GO:2001141]  
1
  • IDAUniProtKB
Response to oxidative stressdefinition[GO:0006979]  
2
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.11.1.15: 2 R'-SH + ROOH R'-S-S-R' + H(2)O + ROH.  
  • CuratedUniProtKB
 
More information is available from:
  • PeroxiBase: 4448 [ HsPrxV ]
Pathways 
According to KEGG, this protein belongs to the following pathway:
Peroxisome  hsa04146+25824  
According to Reactome, this protein belongs to the following pathway:
Cellular responses to stress  REACT_120956  
 

Keywords

Molecular function 
Antioxidant  definition   [KW-0049]
Oxidoreductase  definition   [KW-0560]
Peroxidase  definition   [KW-0575]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PRDX5
GenomeRNAi: 25824
PRO: PR:P30044