ECHS1 - Enoyl-CoA hydratase, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
ECHS1 »  Enoyl-CoA hydratase, mitochondrial   [ EC 4.2.1.17 ]
 
Protein also known as:  Short-chain enoyl-CoA hydratase (SCEH).
Gene name:  ECHS1
Entry whose protein(s) existence is based on evidence at protein level
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1 31 1
GENE REF ISO

Function

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Overview 
Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIHGNC
GO biological process 
Fatty acid beta-oxidationdefinition[GO:0006635]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.17: (3S)-3-hydroxyacyl-CoA trans-2(or 3)-enoyl-CoA + H(2)O.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
beta-Alanine metabolism  hsa00410+1892  
Butanoate metabolism  hsa00650+1892  
Fatty acid elongation  hsa00062+1892  
Fatty acid metabolism  hsa00071+1892  
Lysine degradation  hsa00310+1892  
Metabolic pathways  hsa01100+1892  
Propanoate metabolism  hsa00640+1892  
Tryptophan metabolism  hsa00380+1892  
Valine, leucine and isoleucine degradation  hsa00280+1892  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P30084
Other
GeneWiki: ECHS1
GenomeRNAi: 1892
PRO: PR:P30084