PDIA3 - Protein disulfide-isomerase A3 - human protein (Function)
 
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PDIA3 »  Protein disulfide-isomerase A3   [ EC 5.3.4.1 ]
 
Protein also known as:  Endoplasmic reticulum resident protein 60 (ERp60).
Gene name:  PDIA3
Entry whose protein(s) existence is based on evidence at protein level
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1 101 1
GENE REF ISO

Function

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GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
1
  • TASPINC
Phospholipase C activitydefinition[GO:0004629]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
8
  • IPIUniProtKB
  • IPIIntAct
Protein disulfide isomerase activitydefinition[GO:0003756]  
  • IEAEC 2 GO
Protein disulfide oxidoreductase activitydefinition[GO:0015035] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell redox homeostasisdefinition[GO:0045454] silver  
  • IEAInterPro 2 GO
Glycerol ether metabolic processdefinition[GO:0006662] silver  
  • IEAInterPro 2 GO
Positive regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001238] silver  
  • IEAOrtholog Compara
Protein import into nucleusdefinition[GO:0006606]  
1
  • TASPINC
Protein retention in ER lumendefinition[GO:0006621]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.3.4.1: Catalyzes the rearrangement of -S-S- bonds in proteins.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Antigen processing and presentation  hsa04612+2923  
Protein processing in endoplasmic reticulum  hsa04141+2923  
According to Reactome, this protein belongs to the following pathways:
Immune System  REACT_6900  
Metabolism of proteins  REACT_17015  
Signal Transduction  REACT_111102  
Caution 
Was originally thought to be a phosphatidylinositol 4,5-bisphosphate phosphodiesterase type I (phospholipase C-alpha).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 2923
PRO: PR:P30101