PDIA3 - Protein disulfide-isomerase A3 - human protein (Function)
 
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PDIA3 »  Protein disulfide-isomerase A3   [ EC 5.3.4.1 ]
 
Protein also known as:  Endoplasmic reticulum resident protein 60 (ERp60).
Gene name:  PDIA3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
1
  • PINC
Disulfide oxidoreductase activitydefinition[GO:0015036]  
1
  • ParkinsonsUK-UCL
Phospholipase C activitydefinition[GO:0004629]  
1
  • PINC
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
8
  • UniProtKB
  • IntAct
Protein disulfide isomerase activitydefinition[GO:0003756]  
1
  • RefGenome
GO biological process 
Cell redox homeostasisdefinition[GO:0045454] silver  
1
  • InterPro 2 GO
Oxidation-reduction processdefinition[GO:0055114]  
1
  • GOC
Positive regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001238] silver  
1
  • Ortholog Compara
Protein foldingdefinition[GO:0006457]  
1
  • RefGenome
Protein folding in endoplasmic reticulumdefinition[GO:0034975]  
1
  • ParkinsonsUK-UCL
Protein import into nucleusdefinition[GO:0006606]  
1
  • PINC
Protein retention in ER lumendefinition[GO:0006621]  
1
  • PINC
Proteolysisdefinition[GO:0006508]  
1
  • GOC
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
1
  • RefGenome
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.3.4.1: Catalyzes the rearrangement of -S-S- bonds in proteins.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Antigen processing and presentation  hsa04612+2923  
Protein processing in endoplasmic reticulum  hsa04141+2923  
According to Reactome, this protein belongs to the following pathways:
Antigen Presentation: Folding, assembly and peptide loading of class I MHC  REACT_75795  
Calnexin/calreticulin cycle  REACT_23810  
ER-Phagosome pathway  REACT_111178  
Caution 
Was originally thought to be a phosphatidylinositol 4,5-bisphosphate phosphodiesterase type I (phospholipase C-alpha).  
1
  • UniProtKB
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 2923
PRO: PR:P30101