PPP2R1A - Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform - human protein (Function)
 
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Protein
Gene
References

 
PPP2R1A »  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
 
Protein also known as:  Medium tumor antigen-associated 61 kDa protein.
Gene name:  PPP2R1A
Entry whose protein(s) existence is based on evidence at protein level
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1 101 1
GENE REF ISO

Function

 show evidences
Overview 
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.  
2
  • UniProtKB
GO molecular function 
Antigen bindingdefinition[GO:0003823]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
24
  • IntAct
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • UniProtKB
Protein phosphatase type 2A regulator activitydefinition[GO:0008601]  
1
  • UniProtKB
Protein serine/threonine phosphatase activitydefinition[GO:0004722] silver  
1
  • Ortholog Compara
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB
Ceramide metabolic processdefinition[GO:0006672]  
1
  • UniProtKB
Chromosome segregationdefinition[GO:0007059]  
1
  • UniProtKB
Female meiotic divisiondefinition[GO:0007143] silver  
1
  • Ortholog Compara
Inactivation of MAPK activitydefinition[GO:0000188]  
1
  • UniProtKB
Meiotic sister chromatid cohesion, centromericdefinition[GO:0051754] silver  
1
  • Ortholog Compara
Meiotic spindle elongationdefinition[GO:0051232] silver  
1
  • Ortholog Compara
Mitotic sister chromatid separationdefinition[GO:0051306] silver  
1
  • Ortholog Compara
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • UniProtKB
Negative regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042518]  
1
  • UniProtKB
Peptidyl-serine dephosphorylationdefinition[GO:0070262] silver  
1
  • Ortholog Compara
Positive regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001241] silver  
1
  • Ortholog Compara
Protein complex assemblydefinition[GO:0006461]  
1
  • UniProtKB
Protein dephosphorylationdefinition[GO:0006470]  
1
  • UniProtKB
Regulation of cell adhesiondefinition[GO:0030155]  
1
  • UniProtKB
Regulation of cell differentiationdefinition[GO:0045595]  
1
  • UniProtKB
Regulation of DNA replicationdefinition[GO:0006275]  
1
  • UniProtKB
Regulation of growthdefinition[GO:0040008]  
1
  • UniProtKB
Regulation of meiotic cell cycle process involved in oocyte maturationdefinition[GO:1903538] silver  
1
  • Ortholog Compara
Regulation of protein phosphatase type 2A activitydefinition[GO:0034047]  
2
  • GOC
  • InterPro 2 GO
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Regulation of Wnt signaling pathwaydefinition[GO:0030111]  
1
  • UniProtKB
Response to organic substancedefinition[GO:0010033]  
1
  • UniProtKB
RNA splicingdefinition[GO:0008380]  
1
  • UniProtKB
Second-messenger-mediated signalingdefinition[GO:0019932]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chagas disease (American trypanosomiasis)  hsa05142+5518  
Dopaminergic synapse  hsa04728+5518  
Hepatitis C  hsa05160+5518  
Long-term depression  hsa04730+5518  
mRNA surveillance pathway  hsa03015+5518  
Oocyte meiosis  hsa04114+5518  
TGF-beta signaling pathway  hsa04350+5518  
Tight junction  hsa04530+5518  
Wnt signaling pathway  hsa04310+5518  
According to Reactome, this protein belongs to the following pathways:
Anchoring of the basal body to the plasma membrane  R-HSA-5620912  
APC truncation mutants have impaired AXIN binding  R-HSA-5467337  
AXIN missense mutants destabilize the destruction complex  R-HSA-5467340  
Beta-catenin phosphorylation cascade  R-HSA-196299  
CTLA4 inhibitory signaling  R-HSA-389513  
Cyclin A/B1 associated events during G2/M transition  R-HSA-69273  
Cyclin D associated events in G1  R-HSA-69231  
DARPP-32 events  R-HSA-180024  
Degradation of beta-catenin by the destruction complex  R-HSA-195253  
disassembly of the destruction complex and recruitment of AXIN to the membrane  R-HSA-4641262  
ERK/MAPK targets  R-HSA-198753  
ERKs are inactivated  R-HSA-202670  
Glycolysis  R-HSA-70171  
Inhibition of replication initiation of damaged DNA by RB1/E2F1  R-HSA-113501  
Initiation of Nuclear Envelope Reformation  R-HSA-2995383  
Integration of energy metabolism  R-HSA-163685  
Loss of Nlp from mitotic centrosomes  R-HSA-380259  
Loss of proteins required for interphase microtubule organization from the centrosome  R-HSA-380284  
MASTL Facilitates Mitotic Progression  R-HSA-2465910  
misspliced GSK3beta mutants stabilize beta-catenin  R-HSA-5339716  
Mitotic Prometaphase  R-HSA-68877  
Negative regulation of MAPK pathway  R-HSA-5675221  
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)  R-HSA-975957  
Platelet sensitization by LDL  R-HSA-432142  
PP2A-mediated dephosphorylation of key metabolic factors  R-HSA-163767  
RAF activation  R-HSA-5673000  
Recruitment of mitotic centrosome proteins and complexes  R-HSA-380270  
Regulation of PLK1 Activity at G2/M Transition  R-HSA-2565942  
Resolution of Sister Chromatid Cohesion  R-HSA-2500257  
RHO GTPases Activate Formins  R-HSA-5663220  
S33 mutants of beta-catenin aren't phosphorylated  R-HSA-5358747  
S37 mutants of beta-catenin aren't phosphorylated  R-HSA-5358749  
S45 mutants of beta-catenin aren't phosphorylated  R-HSA-5358751  
Separation of Sister Chromatids  R-HSA-2467813  
Spry regulation of FGF signaling  R-HSA-1295596  
T41 mutants of beta-catenin aren't phosphorylated  R-HSA-5358752  
truncations of AMER1 destabilize the destruction complex  R-HSA-5467348  
 
More information is available from:
 

Keywords

Biological process 
Chromosome partition  definition   [KW-0159]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PPP2R1A
GenomeRNAi: 5518
PRO: PR:P30153