PPP2R1A - Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform - human protein (Function)
 
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PPP2R1A »  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
 
Protein also known as:  Medium tumor antigen-associated 61 kDa protein.
Gene name:  PPP2R1A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.  
1
  • CuratedUniProtKB
GO molecular function 
Antigen bindingdefinition[GO:0003823]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
23
  • IPIIntAct
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIUniProtKB
Protein phosphatase type 2A regulator activitydefinition[GO:0008601]  
1
  • TASUniProtKB
Protein serine/threonine phosphatase activitydefinition[GO:0004722] silver  
  • IEAOrtholog Compara
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • TASUniProtKB
Ceramide metabolic processdefinition[GO:0006672]  
1
  • NASUniProtKB
Chromosome segregationdefinition[GO:0007059]  
1
  • IDAUniProtKB
Inactivation of MAPK activitydefinition[GO:0000188]  
1
  • NASUniProtKB
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • NASUniProtKB
Negative regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042518]  
1
  • NASUniProtKB
Peptidyl-serine dephosphorylationdefinition[GO:0070262] silver  
  • IEAOrtholog Compara
Positive regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001241] silver  
  • IEAOrtholog Compara
Protein complex assemblydefinition[GO:0006461]  
1
  • TASUniProtKB
Protein dephosphorylationdefinition[GO:0006470]  
1
  • TASUniProtKB
Regulation of cell adhesiondefinition[GO:0030155]  
1
  • NASUniProtKB
Regulation of cell differentiationdefinition[GO:0045595]  
1
  • NASUniProtKB
Regulation of DNA replicationdefinition[GO:0006275]  
1
  • NASUniProtKB
Regulation of growthdefinition[GO:0040008]  
1
  • NASUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASUniProtKB
Regulation of Wnt signaling pathwaydefinition[GO:0030111]  
1
  • NASUniProtKB
Response to organic substancedefinition[GO:0010033]  
1
  • NASUniProtKB
RNA splicingdefinition[GO:0008380]  
1
  • NASUniProtKB
Second-messenger-mediated signalingdefinition[GO:0019932]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chagas disease (American trypanosomiasis)  hsa05142+5518  
Dopaminergic synapse  hsa04728+5518  
Hepatitis C  hsa05160+5518  
Long-term depression  hsa04730+5518  
mRNA surveillance pathway  hsa03015+5518  
Oocyte meiosis  hsa04114+5518  
TGF-beta signaling pathway  hsa04350+5518  
Tight junction  hsa04530+5518  
Wnt signaling pathway  hsa04310+5518  
According to Reactome, this protein belongs to the following pathways:
Beta-catenin phosphorylation cascade  REACT_11065  
CTLA4 inhibitory signaling  REACT_19405  
Cyclin A/B1 associated events during G2/M transition  REACT_1857  
Cyclin D associated events in G1  REACT_821  
DARPP-32 events  REACT_15334  
Degradation of beta-catenin by the destruction complex  REACT_11063  
disassembly of the destruction complex and recruitment of AXIN to the membrane  REACT_200610  
ERK/MAPK targets  REACT_12599  
ERKs are inactivated  REACT_12436  
Glycolysis  REACT_1383  
Inhibition of replication initiation of damaged DNA by RB1/E2F1  REACT_329  
Initiation of Nuclear Envelope Reformation  REACT_160242  
Integration of energy metabolism  REACT_1505  
Loss of Nlp from mitotic centrosomes  REACT_15364  
Loss of proteins required for interphase microtubule organization from the centrosome  REACT_15451  
MASTL Facilitates Mitotic Progression  REACT_150182  
Mitotic Prometaphase  REACT_682  
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)  REACT_75822  
Platelet sensitization by LDL  REACT_23879  
PP2A-mediated dephosphorylation of key metabolic factors  REACT_705  
Recruitment of mitotic centrosome proteins and complexes  REACT_15296  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  
Resolution of Sister Chromatid Cohesion  REACT_150425  
Separation of Sister Chromatids  REACT_150471  
Spry regulation of FGF signaling  REACT_111080  
 
More information is available from:
 

Keywords

Biological process 
Chromosome partition  definition   [KW-0159]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PPP2R1A
GenomeRNAi: 5518
PRO: PR:P30153