PPP2R1B - Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform - human protein (Function)
 
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PPP2R1B »  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
 
Protein also known as:  PP2A subunit A isoform PR65-beta.
Gene name:  PPP2R1B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
GO biological process 
Apoptotic process involved in morphogenesisdefinition[GO:0060561]  
1
  • IMPUniProtKB
Positive regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001241]  
1
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chagas disease (American trypanosomiasis)  hsa05142+5519  
Dopaminergic synapse  hsa04728+5519  
Hepatitis C  hsa05160+5519  
Long-term depression  hsa04730+5519  
mRNA surveillance pathway  hsa03015+5519  
Oocyte meiosis  hsa04114+5519  
TGF-beta signaling pathway  hsa04350+5519  
Tight junction  hsa04530+5519  
Wnt signaling pathway  hsa04310+5519  
According to Reactome, this protein belongs to the following pathways:
Beta-catenin phosphorylation cascade  REACT_11065  
CTLA4 inhibitory signaling  REACT_19405  
Cyclin A/B1 associated events during G2/M transition  REACT_1857  
Cyclin D associated events in G1  REACT_821  
DARPP-32 events  REACT_15334  
Degradation of beta-catenin by the destruction complex  REACT_11063  
disassembly of the destruction complex and recruitment of AXIN to the membrane  REACT_200610  
ERK/MAPK targets  REACT_12599  
ERKs are inactivated  REACT_12436  
Glycolysis  REACT_1383  
Inhibition of replication initiation of damaged DNA by RB1/E2F1  REACT_329  
Integration of energy metabolism  REACT_1505  
MASTL Facilitates Mitotic Progression  REACT_150182  
Mitotic Prometaphase  REACT_682  
Platelet sensitization by LDL  REACT_23879  
PP2A-mediated dephosphorylation of key metabolic factors  REACT_705  
Resolution of Sister Chromatid Cohesion  REACT_150425  
Separation of Sister Chromatids  REACT_150471  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PPP2R1B
GenomeRNAi: 5519
PRO: PR:P30154