PPP2R1B - Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform - human protein (Function)
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PPP2R1B »  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Protein also known as:  PP2A subunit A isoform PR65-beta.
Gene name:  PPP2R1B
Entry whose protein(s) existence is based on evidence at protein level
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The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.  
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
  • IntAct
Protein phosphatase type 2A regulator activitydefinition[GO:0008601] silver  
  • InterPro 2 GO
GO biological process 
Apoptotic process involved in morphogenesisdefinition[GO:0060561]  
  • UniProtKB
Positive regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001241]  
  • UniProtKB
Protein complex assemblydefinition[GO:0006461] silver  
  • InterPro 2 GO
Regulation of protein phosphatase type 2A activitydefinition[GO:0034047]  
  • InterPro 2 GO
According to KEGG, this protein belongs to the following pathways:
Chagas disease (American trypanosomiasis)  hsa05142+5519  
Dopaminergic synapse  hsa04728+5519  
Hepatitis C  hsa05160+5519  
Long-term depression  hsa04730+5519  
mRNA surveillance pathway  hsa03015+5519  
Oocyte meiosis  hsa04114+5519  
TGF-beta signaling pathway  hsa04350+5519  
Tight junction  hsa04530+5519  
Wnt signaling pathway  hsa04310+5519  
According to Reactome, this protein belongs to the following pathways:
APC truncation mutants have impaired AXIN binding  R-HSA-5467337  
AXIN missense mutants destabilize the destruction complex  R-HSA-5467340  
Beta-catenin phosphorylation cascade  R-HSA-196299  
CTLA4 inhibitory signaling  R-HSA-389513  
Cyclin A/B1 associated events during G2/M transition  R-HSA-69273  
Cyclin D associated events in G1  R-HSA-69231  
DARPP-32 events  R-HSA-180024  
Degradation of beta-catenin by the destruction complex  R-HSA-195253  
disassembly of the destruction complex and recruitment of AXIN to the membrane  R-HSA-4641262  
ERK/MAPK targets  R-HSA-198753  
ERKs are inactivated  R-HSA-202670  
Glycolysis  R-HSA-70171  
Inhibition of replication initiation of damaged DNA by RB1/E2F1  R-HSA-113501  
Integration of energy metabolism  R-HSA-163685  
MASTL Facilitates Mitotic Progression  R-HSA-2465910  
misspliced GSK3beta mutants stabilize beta-catenin  R-HSA-5339716  
Mitotic Prometaphase  R-HSA-68877  
Negative regulation of MAPK pathway  R-HSA-5675221  
Platelet sensitization by LDL  R-HSA-432142  
PP2A-mediated dephosphorylation of key metabolic factors  R-HSA-163767  
RAF activation  R-HSA-5673000  
Resolution of Sister Chromatid Cohesion  R-HSA-2500257  
RHO GTPases Activate Formins  R-HSA-5663220  
S33 mutants of beta-catenin aren't phosphorylated  R-HSA-5358747  
S37 mutants of beta-catenin aren't phosphorylated  R-HSA-5358749  
S45 mutants of beta-catenin aren't phosphorylated  R-HSA-5358751  
Separation of Sister Chromatids  R-HSA-2467813  
T41 mutants of beta-catenin aren't phosphorylated  R-HSA-5358752  
truncations of AMER1 destabilize the destruction complex  R-HSA-5467348  


Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: PPP2R1B
GenomeRNAi: 5519
PRO: PR:P30154