PPP2R1B - Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform - human protein (Function)
 
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PPP2R1B »  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
 
Protein also known as:  PP2A subunit A isoform PR65-beta.
Gene name:  PPP2R1B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
GO biological process 
Apoptotic process involved in morphogenesisdefinition[GO:0060561]  
1
  • IMPUniProtKB
Positive regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001241]  
1
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chagas disease (American trypanosomiasis)  hsa05142+5519  
Dopaminergic synapse  hsa04728+5519  
Hepatitis C  hsa05160+5519  
Long-term depression  hsa04730+5519  
mRNA surveillance pathway  hsa03015+5519  
Oocyte meiosis  hsa04114+5519  
TGF-beta signaling pathway  hsa04350+5519  
Tight junction  hsa04530+5519  
Wnt signaling pathway  hsa04310+5519  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Disease  REACT_116125  
Hemostasis  REACT_604  
Immune System  REACT_6900  
Metabolism  REACT_111217  
Mitotic M-M/G1 phases  REACT_21300  
Signal Transduction  REACT_111102  
TRAF6 Mediated Induction of proinflammatory cytokines  REACT_6782  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PPP2R1B
GenomeRNAi: 5519
PRO: PR:P30154