CCND2 - G1/S-specific cyclin-D2 - human protein (Function)
 
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Protein
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References

 
CCND2 »  G1/S-specific cyclin-D2
 
Gene name:  CCND2
Family name: Cyclin » Cyclin D
Entry whose protein(s) existence is based on evidence at protein level
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1 89 1
GENE REF ISO

Function

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Overview 
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIBHF-UCL
GO biological process 
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
Cell divisiondefinition[GO:0051301]  
  • IEAUniProtKB KW
Positive regulation of cyclin-dependent protein kinase activitydefinition[GO:0045737]  
1
  • IDABHF-UCL
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+894  
Focal adhesion  hsa04510+894  
HTLV-I infection  hsa05166+894  
Jak-STAT signaling pathway  hsa04630+894  
Measles  hsa05162+894  
p53 signaling pathway  hsa04115+894  
Wnt signaling pathway  hsa04310+894  
According to Reactome, this protein belongs to the following pathway:
Cell Cycle  REACT_115566  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Molecular function 
Cyclin  definition   [KW-0195]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Cyclin_D2
GenomeRNAi: 894
PRO: PR:P30279