CDC25A - M-phase inducer phosphatase 1 - human protein (Function)
 
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CDC25A »  M-phase inducer phosphatase 1   [ EC 3.1.3.48 ]
 
Protein also known as:  Dual specificity phosphatase Cdc25A.
Gene name:  CDC25A
Family name: MPI phosphatase
Entry whose protein(s) existence is based on evidence at protein level
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1 110 2
GENE REF ISO

Function

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Overview 
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Protein tyrosine phosphatase activitydefinition[GO:0004725]  
  • IEAEC 2 GO
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • TASUniProtKB
Cellular response to UVdefinition[GO:0034644]  
1
  • IDAUniProtKB
Mitotic nuclear divisiondefinition[GO:0007067]  
  • IEAUniProtKB KW
Peptidyl-tyrosine dephosphorylationdefinition[GO:0035335]  
  • IEAEC 2 GO
  • IEAInterPro 2 GO
Regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0000079]  
1
  • TASUniProtKB
Response to radiationdefinition[GO:0009314]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.48: Protein tyrosine phosphate + H(2)O protein tyrosine + phosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
Stimulated by B-type cyclins. Stimulated by PIM1-mediated phosphorylation.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+993  
Progesterone-mediated oocyte maturation  hsa04914+993  
According to Reactome, this protein belongs to the following pathways:
Activation of ATR in response to replication stress  REACT_6769  
Cyclin A/B1 associated events during G2/M transition  REACT_1857  
Cyclin A:Cdk2-associated events at S phase entry  REACT_9029  
Cyclin B2 mediated events  REACT_2101  
E2F mediated regulation of DNA replication  REACT_471  
E2F-enabled inhibition of pre-replication complex formation  REACT_1321  
G0 and Early G1  REACT_111214  
G1/S-Specific Transcription  REACT_683  
p53-Independent DNA Damage Response  REACT_2160  
Polo-like kinase mediated events  REACT_1006  
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A  REACT_1614  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Mitosis  definition   [KW-0498]
Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CDC25A
GenomeRNAi: 993
PRO: PR:P30304