BDKRB2 - B2 bradykinin receptor - human protein (Function)
 
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BDKRB2 »  B2 bradykinin receptor  (B2R)
 
Gene name:  BDKRB2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.  
1
  • UniProtKB
GO molecular function 
Beta-2 adrenergic receptor bindingdefinition[GO:0031698] silver  
1
  • Ortholog Compara
Bradykinin receptor activitydefinition[GO:0004947]  
1
  • BHF-UCL
Phosphatidylinositol phospholipase C activitydefinition[GO:0004435]  
1
  • PINC
Protease bindingdefinition[GO:0002020]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • BHF-UCL
Type 1 angiotensin receptor bindingdefinition[GO:0031702]  
1
  • BHF-UCL
GO biological process 
Acute inflammatory response to antigenic stimulusdefinition[GO:0002438] silver  
1
  • Ortholog Compara
Arachidonic acid secretiondefinition[GO:0050482]  
1
  • BHF-UCL
Blood circulationdefinition[GO:0008015]  
1
  • PINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • PINC
Cellular response to hypoxiadefinition[GO:0071456] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB KW
Inflammatory responsedefinition[GO:0006954]  
1
  • BHF-UCL
Maintenance of blood-brain barrierdefinition[GO:0035633] silver  
1
  • Ortholog Compara
Negative regulation of blood pressuredefinition[GO:0045776] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediatordefinition[GO:1902239] silver  
1
  • Ortholog Compara
Negative regulation of peptidyl-serine phosphorylationdefinition[GO:0033137] silver  
1
  • Ortholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
1
  • Ortholog Compara
Regulation of vascular permeabilitydefinition[GO:0043114]  
1
  • BHF-UCL
Regulation of vasoconstrictiondefinition[GO:0019229]  
1
  • BHF-UCL
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to salt stressdefinition[GO:0009651] silver  
1
  • Ortholog Compara
Smooth muscle contractiondefinition[GO:0006939]  
1
  • BHF-UCL
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • PINC
Vasoconstrictiondefinition[GO:0042310] silver  
1
  • InterPro 2 GO
Vasodilationdefinition[GO:0042311] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+624  
Chagas disease (American trypanosomiasis)  hsa05142+624  
Complement and coagulation cascades  hsa04610+624  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+624  
Neuroactive ligand-receptor interaction  hsa04080+624  
Regulation of actin cytoskeleton  hsa04810+624  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  R-HSA-418594  
G alpha (q) signalling events  R-HSA-416476  
Peptide ligand-binding receptors  R-HSA-375276  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Bradykinin_receptor_B2
GenomeRNAi: 624
PRO: PR:P30411
Chemistry
GuidetoPHARMACOLOGY: 42