HLA-C - HLA class I histocompatibility antigen, Cw-1 alpha chain - human protein (Function)
 
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HLA-C »  HLA class I histocompatibility antigen, Cw-1 alpha chain
 
Protein also known as:  MHC class I antigen Cw*1.
Gene name:  HLA-C
Family name: MHC class I
Entry whose protein(s) existence is based on evidence at protein level
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2 197 1
GENE REF ISO

Function

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Overview 
Involved in the presentation of foreign antigens to the immune system.  
1
  • UniProtKB
GO molecular function 
Peptide antigen bindingdefinition[GO:0042605]  
1
  • UniProtKB
TAP bindingdefinition[GO:0046977]  
1
  • UniProtKB
GO biological process 
Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentdefinition[GO:0002486]  
1
  • UniProtKB
Immune responsedefinition[GO:0006955]  
1
  • UniProtKB
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
Antigen Presentation: Folding, assembly and peptide loading of class I MHC  R-HSA-983170  
Endosomal/Vacuolar pathway  R-HSA-1236977  
ER-Phagosome pathway  R-HSA-1236974  
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell  R-HSA-198933  
Interferon alpha/beta signaling  R-HSA-909733  
Interferon gamma signaling  R-HSA-877300  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Immunity  definition   [KW-0391]
Technical term 
Reference proteome  definition   [KW-1185]