AVPR2 - Vasopressin V2 receptor - human protein (Function)
 
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AVPR2 »  Vasopressin V2 receptor  (V2R)
 
Protein also known as:  Renal-type arginine vasopressin receptor.
Gene name:  AVPR2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.  
2
  • UniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.10.3  
GO molecular function 
Peptide bindingdefinition[GO:0042277]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Vasopressin receptor activitydefinition[GO:0005000]  
1
  • UniProtKB
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • PINC
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • PINC
Cellular response to hormone stimulusdefinition[GO:0032870]  
1
  • RefGenome
Excretiondefinition[GO:0007588]  
1
  • PINC
Hemostasisdefinition[GO:0007599]  
1
  • PINC
I-kappaB kinase/NF-kappaB signalingdefinition[GO:0007249] silver  
1
  • Ortholog Compara
Interferon-gamma productiondefinition[GO:0032609] silver  
1
  • Ortholog Compara
Negative regulation of renal sodium excretiondefinition[GO:0035814] silver  
1
  • Ortholog Compara
Negative regulation of urine volumedefinition[GO:0035811] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • Ortholog Curator
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • BHF-UCL
Positive regulation of systemic arterial blood pressuredefinition[GO:0003084] silver  
1
  • Ortholog Compara
Positive regulation of vasoconstrictiondefinition[GO:0045907]  
1
  • RefGenome
Regulation of systemic arterial blood pressure by vasopressindefinition[GO:0001992]  
1
  • RefGenome
Response to cytokinedefinition[GO:0034097] silver  
1
  • Ortholog Compara
Response to peptidedefinition[GO:1901652]  
1
  • RefGenome
Telencephalon developmentdefinition[GO:0021537] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Neuroactive ligand-receptor interaction  hsa04080+554  
Vasopressin-regulated water reabsorption  hsa04962+554  
According to Reactome, this protein belongs to the following pathways:
G alpha (s) signalling events  REACT_19327  
Vasopressin regulates renal water homeostasis via Aquaporins  REACT_24023  
Vasopressin-like receptors  REACT_17041  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Arginine_vasopressin_receptor_2
GenomeRNAi: 554
PRO: PR:P30518
Chemistry
GuidetoPHARMACOLOGY: 368