HMOX2 - Heme oxygenase 2 - human protein (Function)
 
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References

 
HMOX2 »  Heme oxygenase 2   [ EC 1.14.99.3 ]  (HO-2)
 
Gene name:  HMOX2
Family name: Heme oxygenase
Entry whose protein(s) existence is based on evidence at protein level
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1 51 2
GENE REF ISO

Function

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Overview 
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.  
  • CuratedUniProtKB
GO molecular function 
Heme oxygenase (decyclizing) activitydefinition[GO:0004392]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Heme oxidationdefinition[GO:0006788] silver  
  • IEAInterPro 2 GO
Response to hypoxiadefinition[GO:0001666]  
1
  • IDAUniProtKB
Response to oxidative stressdefinition[GO:0006979] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.99.3: Protoheme + 3 AH(2) + 3 O(2) biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Mineral absorption  hsa04978+3163  
Porphyrin and chlorophyll metabolism  hsa00860+3163  
According to Reactome, this protein belongs to the following pathways:
Heme degradation  REACT_22297  
Iron uptake and transport  REACT_25060  
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HMOX2
GenomeRNAi: 3163
PRO: PR:P30519