ADSS - Adenylosuccinate synthetase isozyme 2 - human protein (Function)
 
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ADSS »  Adenylosuccinate synthetase isozyme 2
 
Gene name:  ADSS
Entry whose protein(s) existence is based on evidence at protein level
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1 20 1
GENE REF ISO

Function

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Overview 
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.  
  • CuratedUniProtKB
GO molecular function 
Adenylosuccinate synthase activitydefinition[GO:0004019]  
2
  • NASUniProtKB
GTP bindingdefinition[GO:0005525]  
2
  • NASUniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
  • IEAUniProtKB Annot
Phosphate ion bindingdefinition[GO:0042301]  
2
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
'de novo' AMP biosynthetic processdefinition[GO:0044208]  
  • IEAUniPathway
AMP biosynthetic processdefinition[GO:0006167]  
3
  • NASUniProtKB
Aspartate metabolic processdefinition[GO:0006531] silver  
  • IEAOrtholog Compara
Cellular response to electrical stimulusdefinition[GO:0071257] silver  
  • IEAOrtholog Compara
GTP catabolic processdefinition[GO:0006184] silver  
  • IEAOrtholog Compara
Immune system processdefinition[GO:0002376]  
1
  • NASUniProtKB
IMP metabolic processdefinition[GO:0046040] silver  
  • IEAOrtholog Compara
Response to ammonium iondefinition[GO:0060359] silver  
  • IEAOrtholog Compara
Response to purine-containing compounddefinition[GO:0014074] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.4.4: GTP + IMP + L-aspartate GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 magnesium ion per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+159  
Metabolic pathways  hsa01100+159  
Purine metabolism  hsa00230+159  
According to Reactome, this protein belongs to the following pathway:
Purine ribonucleoside monophosphate biosynthesis  REACT_1776  
 

Keywords

Biological process 
Purine biosynthesis  definition   [KW-0658]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 159
PRO: PR:P30520