ADSS - Adenylosuccinate synthetase isozyme 2 - human protein (Function)
 
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ADSS »  Adenylosuccinate synthetase isozyme 2   [ EC 6.3.4.4 ]  (AdSS 2)
 
Protein also known as:  Adenylosuccinate synthetase, acidic isozyme.
Gene name:  ADSS
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.  
1
  • UniProtKB
GO molecular function 
Adenylosuccinate synthase activitydefinition[GO:0004019]  
2
  • UniProtKB
GTP bindingdefinition[GO:0005525]  
2
  • UniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
1
  • UniProtKB Annot
Phosphate ion bindingdefinition[GO:0042301]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
'de novo' AMP biosynthetic processdefinition[GO:0044208]  
2
  • UniPathway
  • RefGenome
AMP biosynthetic processdefinition[GO:0006167]  
3
  • UniProtKB
Aspartate metabolic processdefinition[GO:0006531] silver  
1
  • Ortholog Compara
Cellular response to electrical stimulusdefinition[GO:0071257] silver  
1
  • Ortholog Compara
Immune system processdefinition[GO:0002376]  
1
  • UniProtKB
IMP metabolic processdefinition[GO:0046040]  
1
  • RefGenome
Response to ammonium iondefinition[GO:0060359] silver  
1
  • Ortholog Compara
Response to purine-containing compounddefinition[GO:0014074] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.4.4: GTP + IMP + L-aspartate GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP.  
2
  • UniProtKB
  • HAMAP-Rule
It requires the following cofactor
 Mg(2+) : Binds 1 Mg(2+) ion per subunit.  
2
  • HAMAP-Rule
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2  
2
  • UniProtKB
  • HAMAP-Rule
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+159  
Metabolic pathways  hsa01100+159  
Purine metabolism  hsa00230+159  
According to Reactome, this protein belongs to the following pathway:
Purine ribonucleoside monophosphate biosynthesis  REACT_1776  
 

Keywords

Biological process 
Purine biosynthesis  definition   [KW-0658]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 159
PRO: PR:P30520