AXL - Tyrosine-protein kinase receptor UFO - human protein (Function)
 
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AXL »  Tyrosine-protein kinase receptor UFO   [ EC 2.7.10.1 ]
 
Protein also known as:  AXL oncogene.
Gene name:  AXL
Entry whose protein(s) existence is based on evidence at protein level
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1 139 2
GENE REF ISO

Function

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Overview 
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.  
9
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Myosin heavy chain bindingdefinition[GO:0032036] silver  
  • IEAOrtholog Compara
Phosphatidylinositol 3-kinase bindingdefinition[GO:0043548] silver  
  • IEAOrtholog Compara
Phosphatidylserine bindingdefinition[GO:0001786]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IPIUniProtKB
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Transmembrane receptor protein tyrosine kinase activitydefinition[GO:0004714]  
  • IEAEC 2 GO
GO biological process 
Apoptotic cell clearancedefinition[GO:0043277] silver  
  • IEAOrtholog Compara
Blood vessel remodelingdefinition[GO:0001974] silver  
  • IEAOrtholog Compara
Cell maturationdefinition[GO:0048469]  
1
  • IEPUniProtKB
Cellular response to extracellular stimulusdefinition[GO:0031668] silver  
  • IEAOrtholog Compara
Cellular response to hydrogen peroxidedefinition[GO:0070301] silver  
  • IEAOrtholog Compara
Cellular response to interferon-alphadefinition[GO:0035457]  
1
  • IDAUniProtKB
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • IDAUniProtKB
Dendritic cell differentiationdefinition[GO:0097028]  
1
  • IEPUniProtKB
Enzyme linked receptor protein signaling pathwaydefinition[GO:0007167] silver  
  • IEAOrtholog Compara
Erythrocyte homeostasisdefinition[GO:0034101] silver  
  • IEAOrtholog Compara
Forebrain cell migrationdefinition[GO:0021885] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Innate immune responsedefinition[GO:0045087]  
  • IEAUniProtKB KW
Natural killer cell differentiationdefinition[GO:0001779] silver  
  • IEAOrtholog Compara
Negative regulation of dendritic cell apoptotic processdefinition[GO:2000669]  
1
  • IDAUniProtKB
Negative regulation of interferon-gamma productiondefinition[GO:0032689]  
1
  • IDAUniProtKB
Negative regulation of lymphocyte activationdefinition[GO:0051250] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720] silver  
  • IEAOrtholog Compara
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Ovulation cycledefinition[GO:0042698] silver  
  • IEAOrtholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • TASGOC
Phagocytosisdefinition[GO:0006909]  
1
  • IDAUniProtKB
Platelet activationdefinition[GO:0030168] silver  
  • IEAOrtholog Compara
Positive regulation of cytokine-mediated signaling pathwaydefinition[GO:0001961]  
1
  • IDAUniProtKB
Positive regulation of natural killer cell differentiationdefinition[GO:0032825]  
1
  • IDAUniProtKB
Positive regulation of protein kinase B signalingdefinition[GO:0051897] silver  
  • IEAOrtholog Compara
Protein kinase B signalingdefinition[GO:0043491] silver  
  • IEAOrtholog Compara
Secretion by celldefinition[GO:0032940] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446] silver  
  • IEAOrtholog Compara
Vagina developmentdefinition[GO:0060068] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by GAS6-binding and subsequent autophosphorylation.  
2
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: AXL_receptor_tyrosine_kinase
GenomeRNAi: 558
PRO: PR:P30530
Chemistry
GuidetoPHARMACOLOGY: 1835