AXL - Tyrosine-protein kinase receptor UFO - human protein (Function)
 
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AXL »  Tyrosine-protein kinase receptor UFO   [ EC 2.7.10.1 ]
 
Protein also known as:  AXL oncogene.
Gene name:  AXL
Entry whose protein(s) existence is based on evidence at protein level
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1 157 2
GENE REF ISO

Function

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Overview 
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.  
10
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Myosin heavy chain bindingdefinition[GO:0032036] silver  
1
  • Ortholog Compara
Phosphatidylinositol 3-kinase bindingdefinition[GO:0043548] silver  
1
  • Ortholog Compara
Phosphatidylserine bindingdefinition[GO:0001786]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • UniProtKB
  • IntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Transmembrane receptor protein tyrosine kinase activitydefinition[GO:0004714]  
1
  • EC 2 GO
GO biological process 
Apoptotic cell clearancedefinition[GO:0043277] silver  
1
  • Ortholog Compara
Blood vessel remodelingdefinition[GO:0001974] silver  
1
  • Ortholog Compara
Cell maturationdefinition[GO:0048469]  
1
  • UniProtKB
Cellular response to extracellular stimulusdefinition[GO:0031668] silver  
1
  • Ortholog Compara
Cellular response to hydrogen peroxidedefinition[GO:0070301] silver  
1
  • Ortholog Compara
Cellular response to interferon-alphadefinition[GO:0035457]  
1
  • UniProtKB
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • UniProtKB
Dendritic cell differentiationdefinition[GO:0097028]  
1
  • UniProtKB
Enzyme linked receptor protein signaling pathwaydefinition[GO:0007167] silver  
1
  • Ortholog Compara
Erythrocyte homeostasisdefinition[GO:0034101] silver  
1
  • Ortholog Compara
Forebrain cell migrationdefinition[GO:0021885] silver  
1
  • Ortholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
1
  • Ortholog Compara
Innate immune responsedefinition[GO:0045087]  
1
  • UniProtKB KW
Natural killer cell differentiationdefinition[GO:0001779] silver  
1
  • Ortholog Compara
Negative regulation of dendritic cell apoptotic processdefinition[GO:2000669]  
1
  • UniProtKB
Negative regulation of interferon-gamma productiondefinition[GO:0032689]  
1
  • UniProtKB
Negative regulation of lymphocyte activationdefinition[GO:0051250] silver  
1
  • Ortholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720] silver  
1
  • Ortholog Compara
Neuron migrationdefinition[GO:0001764] silver  
1
  • Ortholog Compara
Organ regenerationdefinition[GO:0031100] silver  
1
  • Ortholog Compara
Ovulation cycledefinition[GO:0042698] silver  
1
  • Ortholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
4
  • GOC
  • InterPro 2 GO
  • UniProtKB KW
  • EC 2 GO
Phagocytosisdefinition[GO:0006909]  
1
  • UniProtKB
Platelet activationdefinition[GO:0030168] silver  
1
  • Ortholog Compara
Positive regulation of cytokine-mediated signaling pathwaydefinition[GO:0001961]  
1
  • UniProtKB
Positive regulation of natural killer cell differentiationdefinition[GO:0032825]  
1
  • UniProtKB
Positive regulation of protein kinase B signalingdefinition[GO:0051897] silver  
1
  • Ortholog Compara
Protein kinase B signalingdefinition[GO:0043491] silver  
1
  • Ortholog Compara
Secretion by celldefinition[GO:0032940] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446] silver  
1
  • Ortholog Compara
Vagina developmentdefinition[GO:0060068] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • UniProtKB
  • PROSITE-ProRule
It is regulated in the following manner
Activated by GAS6-binding and subsequent autophosphorylation.  
3
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
VEGFA-VEGFR2 Pathway  REACT_228166  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: AXL_receptor_tyrosine_kinase
GenomeRNAi: 558
PRO: PR:P30530
Chemistry
GuidetoPHARMACOLOGY: 1835