ADORA1 - Adenosine receptor A1 - human protein (Function)
 
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ADORA1 »  Adenosine receptor A1
 
Gene name:  ADORA1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.3.4  
GO molecular function 
G-protein beta/gamma-subunit complex bindingdefinition[GO:0031683] silver  
  • IEAOrtholog Compara
G-protein coupled adenosine receptor activitydefinition[GO:0001609] silver  
  • IEAInterPro 2 GO
G-protein coupled receptor bindingdefinition[GO:0001664] silver  
  • IEAOrtholog Compara
Heterotrimeric G-protein bindingdefinition[GO:0032795] silver  
  • IEAOrtholog Compara
Phospholipase C activitydefinition[GO:0004629] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Purine nucleoside bindingdefinition[GO:0001883] silver  
  • IEAOrtholog Compara
GO biological process 
Activation of MAPKK activitydefinition[GO:0000186] silver  
  • IEAOrtholog Compara
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193] silver  
  • IEAOrtholog Compara
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • TASPINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Cognitiondefinition[GO:0050890] silver  
  • IEAOrtholog Compara
Detection of temperature stimulus involved in sensory perception of paindefinition[GO:0050965] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Lipid catabolic processdefinition[GO:0016042] silver  
  • IEAOrtholog Compara
Negative regulation of acute inflammatory responsedefinition[GO:0002674] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of blood pressuredefinition[GO:0045776] silver  
  • IEAOrtholog Compara
Negative regulation of cardiac muscle contractiondefinition[GO:0055118] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of circadian sleep/wake cycle, non-REM sleepdefinition[GO:0042323] silver  
  • IEAOrtholog Compara
Negative regulation of glutamate secretiondefinition[GO:0014050] silver  
  • IEAOrtholog Compara
Negative regulation of heart contractiondefinition[GO:0045822] silver  
  • IEAOrtholog Compara
Negative regulation of hormone secretiondefinition[GO:0046888] silver  
  • IEAOrtholog Compara
Negative regulation of leukocyte migrationdefinition[GO:0002686] silver  
  • IEAOrtholog Compara
Negative regulation of lipid catabolic processdefinition[GO:0050995] silver  
  • IEAOrtholog Compara
Negative regulation of mucus secretiondefinition[GO:0070256] silver  
  • IEAOrtholog Compara
Negative regulation of neurotrophin productiondefinition[GO:0032900] silver  
  • IEAOrtholog Compara
Negative regulation of renal sodium excretiondefinition[GO:0035814] silver  
  • IEAOrtholog Compara
Negative regulation of synaptic transmission, GABAergicdefinition[GO:0032229] silver  
  • IEAOrtholog Compara
Negative regulation of synaptic transmission, glutamatergicdefinition[GO:0051967] silver  
  • IEAOrtholog Compara
Negative regulation of vasodilationdefinition[GO:0045908] silver  
  • IEAOrtholog Compara
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Phagocytosisdefinition[GO:0006909]  
1
  • TASPINC
Positive regulation of blood pressuredefinition[GO:0045777] silver  
  • IEAOrtholog Compara
Positive regulation of epidermal growth factor-activated receptor activitydefinition[GO:0045741] silver  
  • IEAOrtholog Compara
Positive regulation of nucleoside transportdefinition[GO:0032244] silver  
  • IEAOrtholog Compara
Positive regulation of peptide secretiondefinition[GO:0002793] silver  
  • IEAOrtholog Compara
Positive regulation of potassium ion transportdefinition[GO:0043268] silver  
  • IEAOrtholog Compara
Positive regulation of protein dephosphorylationdefinition[GO:0035307] silver  
  • IEAOrtholog Compara
Protein targeting to membranedefinition[GO:0006612] silver  
  • IEAOrtholog Compara
Regulation of excitatory postsynaptic membrane potentialdefinition[GO:0060079] silver  
  • IEAOrtholog Compara
Regulation of glomerular filtrationdefinition[GO:0003093] silver  
  • IEAOrtholog Compara
Regulation of respiratory gaseous exchange by neurological system processdefinition[GO:0002087] silver  
  • IEAOrtholog Compara
Regulation of synaptic plasticitydefinition[GO:0048167] silver  
  • IEAOrtholog Compara
Relaxation of vascular smooth muscledefinition[GO:0060087] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Temperature homeostasisdefinition[GO:0001659] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+134  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Adenosine_A1_receptor
GenomeRNAi: 134
PRO: PR:P30542
Chemistry
GuidetoPHARMACOLOGY: 18