AGTR1 - Type-1 angiotensin II receptor - human protein (Function)
 
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AGTR1 »  Type-1 angiotensin II receptor
 
Protein also known as:  Angiotensin II type-1 receptor (AT1).
Gene name:  AGTR1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 346 1
GENE REF ISO

Function

 show evidences
Overview 
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.13.1  
GO molecular function 
Angiotensin type I receptor activitydefinition[GO:0001596]  
2
  • IDABHF-UCL
Angiotensin type II receptor activitydefinition[GO:0004945]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Bradykinin receptor bindingdefinition[GO:0031711]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
GO biological process 
Angiotensin-activated signaling pathwaydefinition[GO:0038166]  
4
  • IDAGOC
Calcium-mediated signalingdefinition[GO:0019722]  
1
  • IDABHF-UCL
Cell chemotaxisdefinition[GO:0060326]  
1
  • IDAUniProtKB
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDABHF-UCL
Kidney developmentdefinition[GO:0001822]  
1
  • IMPBHF-UCL
Low-density lipoprotein particle remodelingdefinition[GO:0034374]  
1
  • NASBHF-UCL
Phospholipase C-activating angiotensin-activated signaling pathwaydefinition[GO:0086097]  
2
  • IDAGOC
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
1
  • NASBHF-UCL
Positive regulation of cellular protein metabolic processdefinition[GO:0032270]  
1
  • IMPBHF-UCL
Positive regulation of cholesterol esterificationdefinition[GO:0010873]  
1
  • IMPBHF-UCL
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • IDABHF-UCL
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwaydefinition[GO:0051482]  
1
  • IDABHF-UCL
Positive regulation of inflammatory responsedefinition[GO:0050729]  
1
  • TASBHF-UCL
Positive regulation of macrophage derived foam cell differentiationdefinition[GO:0010744]  
1
  • ICBHF-UCL
Positive regulation of NAD(P)H oxidase activitydefinition[GO:0033864]  
1
  • TASBHF-UCL
Positive regulation of phospholipase A2 activitydefinition[GO:0032430]  
1
  • IMPBHF-UCL
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379]  
1
  • TASBHF-UCL
Regulation of blood vessel size by renin-angiotensindefinition[GO:0002034]  
1
  • ICBHF-UCL
Regulation of cell growthdefinition[GO:0001558]  
1
  • NASBHF-UCL
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • NASBHF-UCL
Regulation of inflammatory responsedefinition[GO:0050727]  
1
  • ICBHF-UCL
Regulation of renal sodium excretiondefinition[GO:0035813]  
1
  • NASBHF-UCL
Regulation of systemic arterial blood pressure by renin-angiotensindefinition[GO:0003081]  
1
  • ICBHF-UCL
Regulation of vasoconstrictiondefinition[GO:0019229]  
3
  • NASBHF-UCL
Regulation of vasodilationdefinition[GO:0042312]  
1
  • ICBHF-UCL
Renin-angiotensin regulation of aldosterone productiondefinition[GO:0002018]  
1
  • NASBHF-UCL
Rho protein signal transductiondefinition[GO:0007266]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+185  
Neuroactive ligand-receptor interaction  hsa04080+185  
Renin-angiotensin system  hsa04614+185  
Vascular smooth muscle contraction  hsa04270+185  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Angiotensin_II_receptor_type_1
GenomeRNAi: 185
PRO: PR:P30556
Chemistry
GuidetoPHARMACOLOGY: 34