ADSL - Adenylosuccinate lyase - human protein (Function)
 
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ADSL »  Adenylosuccinate lyase   [ EC 4.3.2.2 ]  (ASL)
 
Protein also known as:  Adenylosuccinase (ASase).
Gene name:  ADSL
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.  
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  • UniProtKB
GO molecular function 
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activitydefinition[GO:0070626]  
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  • EC 2 GO
Isoform  Iso 1 but not isoform  Iso 2   N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activitydefinition[GO:0004018]  
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  • UniProtKB
GO biological process 
'de novo' AMP biosynthetic processdefinition[GO:0044208]  
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  • UniPathway
'de novo' IMP biosynthetic processdefinition[GO:0006189]  
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  • UniPathway
AMP biosynthetic processdefinition[GO:0006167]  
1
  • UniProtKB
Isoform  Iso 1   Metabolic processdefinition[GO:0008152]  
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  • GOC
Protein tetramerizationdefinition[GO:0051262]  
1
  • UniProtKB
Purine nucleotide biosynthetic processdefinition[GO:0006164]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
N(6)-(1,2-dicarboxyethyl)AMP fumarate + AMP.  
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  • UniProtKB
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.  
1
  • UniProtKB
It is regulated in the following manner
The enzyme reaction kinetics indicate cooperativity between subunits.  
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  • UniProtKB
Pathways 
This protein is involved in the following pathways
Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+158  
Metabolic pathways  hsa01100+158  
Purine metabolism  hsa00230+158  
According to Reactome, this protein belongs to the following pathway:
Purine ribonucleoside monophosphate biosynthesis  REACT_1776  
 
More information is available from:
 

Keywords

Biological process 
Purine biosynthesis  definition   [KW-0658]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P30566
Other
GeneWiki: Adenylosuccinate_lyase
GenomeRNAi: 158
PRO: PR:P30566