PKLR - Pyruvate kinase PKLR - human protein (Function)
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PKLR »  Pyruvate kinase PKLR   [ EC ]
Protein also known as:  Red cell/liver pyruvate kinase.
Gene name:  PKLR
Family name: Pyruvate kinase
Entry whose protein(s) existence is based on evidence at protein level
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Plays a key role in glycolysis (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAInterPro 2 GO
Potassium ion bindingdefinition[GO:0030955] silver  
  • IEAInterPro 2 GO
Pyruvate kinase activitydefinition[GO:0004743]  
  • IEAEC 2 GO
GO biological process 
ATP biosynthetic processdefinition[GO:0006754] silver  
  • IEAOrtholog Compara
Cellular response to insulin stimulusdefinition[GO:0032869] silver  
  • IEAOrtholog Compara
Glycolytic processdefinition[GO:0006096]  
  • IEAUniPathway
  • IEAUniProtKB KW
Pyruvate biosynthetic processdefinition[GO:0042866] silver  
  • IEAOrtholog Compara
Response to ATPdefinition[GO:0033198] silver  
  • IEAOrtholog Compara
Response to cAMPdefinition[GO:0051591] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Response to heatdefinition[GO:0009408] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to lithium iondefinition[GO:0010226] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Response to other organismdefinition[GO:0051707] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC ATP + pyruvate ADP + phosphoenolpyruvate.  
  • CuratedUniProtKB
It requires the following cofactors
  • CuratedUniProtKB
  • CuratedUniProtKB
It is regulated in the following manner
Allosterically activated by fructose 1,6-bisphosphate.  
  • CuratedUniProtKB
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycolysis / Gluconeogenesis  hsa00010+5313  
Insulin signaling pathway  hsa04910+5313  
Maturity onset diabetes of the young  hsa04950+5313  
Metabolic pathways  hsa01100+5313  
Purine metabolism  hsa00230+5313  
Pyruvate metabolism  hsa00620+5313  
Type II diabetes mellitus  hsa04930+5313  
According to Reactome, this protein belongs to the following pathways:
ChREBP activates metabolic gene expression  REACT_2122  
Glycolysis  REACT_1383  
Regulation of gene expression in beta cells  REACT_13819  
More information is available from:
There are 4 isozymes of pyruvate kinase in mammals: L, R, M1 and M2. L type is major isozyme in the liver, R is found in red cells, M1 is the main form in muscle, heart and brain, and M2 is found in early fetal tissues.  
  • CuratedUniProtKB


Biological process 
Glycolysis  definition   [KW-0324]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]

Further external links

Enzyme and pathway databases
SABIO-RK: P30613
GeneWiki: PKLR
GenomeRNAi: 5313
PRO: PR:P30613