SRI - Sorcin - human protein (Function)
 
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Protein
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References

 
SRI »  Sorcin
 
Protein also known as:  22 kDa protein.
Gene name:  SRI
Entry whose protein(s) existence is based on evidence at protein level
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1 51 2
GENE REF ISO

Function

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Overview 
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.  
1
  • CuratedUniProtKB
GO molecular function 
Calcium channel regulator activitydefinition[GO:0005246]  
1
  • TASPINC
Calcium ion bindingdefinition[GO:0005509]  
1
  • IDABHF-UCL
Ion channel bindingdefinition[GO:0044325]  
1
  • TASBHF-UCL
Protease bindingdefinition[GO:0002020]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
Receptor bindingdefinition[GO:0005102]  
1
  • TASPINC
Repressing transcription factor bindingdefinition[GO:0070491] silver  
  • IEAOrtholog Compara
GO biological process 
Action potentialdefinition[GO:0001508]  
1
  • TASPINC
Calcium ion transportdefinition[GO:0006816] silver  
  • IEAOrtholog Compara
Cytoplasmic sequestering of transcription factordefinition[GO:0042994] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507]  
1
  • TASPINC
Intracellular sequestering of iron iondefinition[GO:0006880]  
1
  • TASPINC
Muscle organ developmentdefinition[GO:0007517]  
1
  • TASPINC
Negative regulation of heart ratedefinition[GO:0010459]  
1
  • IMPBHF-UCL
Negative regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060315]  
1
  • IDABHF-UCL
Negative regulation of transcription regulatory region DNA bindingdefinition[GO:2000678] silver  
  • IEAOrtholog Compara
Positive regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0035774] silver  
  • IEAOrtholog Compara
Positive regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051281] silver  
  • IEAOrtholog Compara
Regulation of calcium ion transportdefinition[GO:0051924]  
2
  • IMPBHF-UCL
Regulation of cardiac muscle cell contractiondefinition[GO:0086004]  
2
  • IMPBHF-UCL
Regulation of cell communication by electrical couplingdefinition[GO:0010649]  
1
  • TASBHF-UCL
Regulation of cell communication by electrical coupling involved in cardiac conductiondefinition[GO:1901844]  
1
  • IMPBHF-UCL
Regulation of heart contractiondefinition[GO:0008016]  
1
  • TASPINC
Regulation of high voltage-gated calcium channel activitydefinition[GO:1901841]  
1
  • IMPBHF-UCL
Regulation of relaxation of muscledefinition[GO:1901077]  
1
  • IMPBHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumdefinition[GO:0010880]  
1
  • TASBHF-UCL
Regulation of striated muscle contractiondefinition[GO:0006942]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • TASUniProtKB
Transportdefinition[GO:0006810]  
1
  • TASPINC
Note 
This protein is encoded by an amplified gene in multidrug-resistant cells.  
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SRI_(gene)
GenomeRNAi: 6717
PRO: PR:P30626