ALDH3A1 - Aldehyde dehydrogenase, dimeric NADP-preferring - human protein (Function)
 
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ALDH3A1 »  Aldehyde dehydrogenase, dimeric NADP-preferring   [ EC 1.2.1.5 ]
 
Protein also known as:  Aldehyde dehydrogenase family 3 member A1.
Gene name:  ALDH3A1
Family name: Aldehyde dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
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1 37 1
GENE REF ISO

Function

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Overview 
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.  
  • CuratedUniProtKB
GO molecular function 
3-chloroallyl aldehyde dehydrogenase activitydefinition[GO:0004028] silver  
  • IEAOrtholog Compara
Alcohol dehydrogenase (NADP+) activitydefinition[GO:0008106]  
1
  • IDAUniProtKB
Aldehyde dehydrogenase (NAD) activitydefinition[GO:0004029]  
1
  • IDAUniProtKB
Aldehyde dehydrogenase [NAD(P)+] activitydefinition[GO:0004030]  
  • IEAEC 2 GO
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Cellular aldehyde metabolic processdefinition[GO:0006081]  
1
  • IDAUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Response to cAMPdefinition[GO:0051591] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.2.1.5: An aldehyde + NAD(P)(+) + H(2)O a carboxylate + NAD(P)H.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
beta-Alanine metabolism  hsa00410+218  
Drug metabolism - cytochrome P450  hsa00982+218  
Glycolysis / Gluconeogenesis  hsa00010+218  
Histidine metabolism  hsa00340+218  
Metabolic pathways  hsa01100+218  
Metabolism of xenobiotics by cytochrome P450  hsa00980+218  
Phenylalanine metabolism  hsa00360+218  
Tyrosine metabolism  hsa00350+218  
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P30838
Other
GeneWiki: Aldehyde_dehydrogenase_3_family,_member_A1
GenomeRNAi: 218
PRO: PR:P30838