SSTR1 - Somatostatin receptor type 1 - human protein (Function)
 
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SSTR1 »  Somatostatin receptor type 1  (SS1R)
 
Protein also known as:  SRIF-2.
Gene name:  SSTR1
Entry whose protein(s) existence is based on evidence at protein level
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1 43 1
GENE REF ISO

Function

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Overview 
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.  
  • CuratedUniProtKB
GO molecular function 
Somatostatin receptor activitydefinition[GO:0004994]  
1
  • IDAMGI
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Cellular response to estradiol stimulusdefinition[GO:0071392] silver  
  • IEAOrtholog Compara
Cerebellum developmentdefinition[GO:0021549] silver  
  • IEAOrtholog Compara
Digestiondefinition[GO:0007586]  
1
  • TASPINC
Forebrain developmentdefinition[GO:0030900] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
1
  • TASPINC
Glutamate receptor signaling pathwaydefinition[GO:0007215] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Neuropeptide signaling pathwaydefinition[GO:0007218] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584]  
1
  • TASPINC
Response to starvationdefinition[GO:0042594] silver  
  • IEAOrtholog Compara
Somatostatin signaling pathwaydefinition[GO:0038170] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+6751  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
Peptide ligand-binding receptors  REACT_14819  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Somatostatin_receptor_1
GenomeRNAi: 6751
PRO: PR:P30872
Chemistry
GuidetoPHARMACOLOGY: 355