CALCR - Calcitonin receptor - human protein (Function)
 
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CALCR »  Calcitonin receptor  (CT-R)
 
Gene name:  CALCR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 68 6
GENE REF ISO

Function

 show evidences
Overview 
This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.4.1  
GO molecular function 
Calcitonin bindingdefinition[GO:0032841]  
6
  • IDAUniProtKB
Calcitonin receptor activitydefinition[GO:0004948]  
1
  • IDAUniProtKB
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Protein transporter activitydefinition[GO:0008565]  
1
  • IDAUniProtKB
Receptor activitydefinition[GO:0004872]  
2
  • IDAUniProtKB
GO biological process 
Not  Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • IDAUniProtKB
Not Isoform  Iso 1   Activation of phospholipase C activitydefinition[GO:0007202]  
1
  • IDAUniProtKB
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189]  
2
  • IDAUniProtKB
Isoforms  Iso 1 and Iso 3   G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDAGOC
Positive regulation of adenylate cyclase activitydefinition[GO:0045762]  
3
  • IDAUniProtKB
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819]  
1
  • IDAUniProtKB
Isoform  Iso 2   Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • IDAUniProtKB
Protein localization to plasma membranedefinition[GO:0072659]  
1
  • IDAUniProtKB
Protein transportdefinition[GO:0015031]  
1
  • IDAUniProtKB
Receptor internalizationdefinition[GO:0031623]  
1
  • IDAUniProtKB
Response to glucocorticoiddefinition[GO:0051384]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Neuroactive ligand-receptor interaction  hsa04080+799  
Osteoclast differentiation  hsa04380+799  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Calcitonin_receptor
GenomeRNAi: 799
PRO: PR:P30988
Chemistry
GuidetoPHARMACOLOGY: 43