NTSR1 - Neurotensin receptor type 1 - human protein (Function)
 
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NTSR1 »  Neurotensin receptor type 1  (NTR1)
 
Protein also known as:  High-affinity levocabastine-insensitive neurotensin receptor.
Gene name:  NTSR1
Entry whose protein(s) existence is based on evidence at protein level
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1 57 1
GENE REF ISO

Function

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Overview 
G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.  
4
  • UniProtKB
GO molecular function 
G-protein coupled neurotensin receptor activitydefinition[GO:0016492]  
2
  • UniProtKB
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • PINC
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Adult locomotory behaviordefinition[GO:0008344] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • PINC
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Neuropeptide signaling pathwaydefinition[GO:0007218]  
1
  • UniProtKB
Synaptic transmissiondefinition[GO:0007268]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+4923  
Neuroactive ligand-receptor interaction  hsa04080+4923  
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
Peptide ligand-binding receptors  REACT_14819  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Neurotensin_receptor_1
GenomeRNAi: 4923
PRO: PR:P30989
Chemistry
GuidetoPHARMACOLOGY: 309