NTSR1 - Neurotensin receptor type 1 - human protein (Function)
 
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NTSR1 »  Neurotensin receptor type 1  (NTR1)
 
Protein also known as:  High-affinity levocabastine-insensitive neurotensin receptor.
Gene name:  NTSR1
Entry whose protein(s) existence is based on evidence at protein level
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1 74 1
GENE REF ISO

Function

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Overview 
G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed8381365, PubMed21725197, PubMed23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed21725197).  
4
  • UniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.1.14  
GO molecular function 
G-protein coupled neurotensin receptor activitydefinition[GO:0016492]  
2
  • UniProtKB
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • PINC
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
Protein N-terminus bindingdefinition[GO:0047485] silver  
1
  • Ortholog Compara
GO biological process 
Adult locomotory behaviordefinition[GO:0008344] silver  
1
  • Ortholog Compara
D-aspartate importdefinition[GO:0070779] silver  
1
  • Ortholog Compara
Detection of temperature stimulus involved in sensory perception of paindefinition[GO:0050965] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • PINC
Inositol phosphate catabolic processdefinition[GO:0071545] silver  
1
  • Ortholog Compara
L-glutamate import into celldefinition[GO:1990123] silver  
1
  • Ortholog Compara
Learningdefinition[GO:0007612] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051280] silver  
1
  • Ortholog Compara
Negative regulation of systemic arterial blood pressuredefinition[GO:0003085] silver  
1
  • Ortholog Compara
Neuropeptide signaling pathwaydefinition[GO:0007218]  
1
  • UniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
1
  • Ortholog Compara
Positive regulation of arachidonic acid secretiondefinition[GO:0090238] silver  
1
  • Ortholog Compara
Positive regulation of cation channel activitydefinition[GO:2001259] silver  
1
  • Ortholog Compara
Positive regulation of gamma-aminobutyric acid secretiondefinition[GO:0014054] silver  
1
  • Ortholog Compara
Positive regulation of glutamate secretiondefinition[GO:0014049] silver  
1
  • Ortholog Compara
Positive regulation of inhibitory postsynaptic potentialdefinition[GO:0097151] silver  
1
  • Ortholog Compara
Positive regulation of inositol phosphate biosynthetic processdefinition[GO:0060732] silver  
1
  • Ortholog Compara
Positive regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051281] silver  
1
  • Ortholog Compara
Regulation of action potentialdefinition[GO:0098900] silver  
1
  • Ortholog Compara
Regulation of membrane depolarizationdefinition[GO:0003254] silver  
1
  • Ortholog Compara
Regulation of respiratory gaseous exchangedefinition[GO:0043576] silver  
1
  • Ortholog Compara
Regulation of sensory perception of paindefinition[GO:0051930] silver  
1
  • Ortholog Compara
Response to lipiddefinition[GO:0033993] silver  
1
  • Ortholog Compara
Synaptic transmissiondefinition[GO:0007268]  
1
  • PINC
Temperature homeostasisdefinition[GO:0001659] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+4923  
Neuroactive ligand-receptor interaction  hsa04080+4923  
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  R-HSA-416476  
Peptide ligand-binding receptors  R-HSA-375276  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Neurotensin_receptor_1
GenomeRNAi: 4923
PRO: PR:P30989
Chemistry
GuidetoPHARMACOLOGY: 309