SDHA - Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial - human protein (Function)
 
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SDHA »  Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial   [ EC 1.3.5.1 ]
 
Protein also known as:  Flavoprotein subunit of complex II (Fp).
Gene name:  SDHA
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor.  
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  • CuratedUniProtKB
GO molecular function 
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
Succinate dehydrogenase (ubiquinone) activitydefinition[GO:0008177]  
  • IEAEC 2 GO
Contributes to succinate dehydrogenase activitydefinition[GO:0000104]  
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  • IMPUniProtKB
GO biological process 
Nervous system developmentdefinition[GO:0007399]  
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  • IMPUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAUniProtKB
Respiratory electron transport chaindefinition[GO:0022904]  
1
  • IDAUniProtKB
Succinate metabolic processdefinition[GO:0006105]  
1
  • IDAUniProtKB
Tricarboxylic acid cycledefinition[GO:0006099]  
1
  • TASUniProtKB
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.3.5.1: Succinate + ubiquinone fumarate + ubiquinol.  
  • CuratedUniProtKB
It requires the following cofactor
FAD.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+6389  
Citrate cycle (TCA cycle)  hsa00020+6389  
Huntington's disease  hsa05016+6389  
Metabolic pathways  hsa01100+6389  
Oxidative phosphorylation  hsa00190+6389  
Parkinson's disease  hsa05012+6389  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
Note 
The complex, present in mitochondria, can be degraded to form EC 1.3.99.1, which no longer reacts with ubiquinone.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Transport  definition   [KW-0813]
Tricarboxylic acid cycle  definition   [KW-0816]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SDHA
GenomeRNAi: 6389
PRO: PR:P31040